Pure Flat Epithelial Atypia of the Breast on Core Needle Biopsy: No Need for Surgical Excision

Authors

  • Warapan Numprasit Department of Surgery, Faculty of Medicine Siriraj Hospital Mahidol University, Bangkok
  • Norasate Samarnthai Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
  • Tichakorn Srianuchat Thanyarak Breast Center, Siriraj Hospital, Bangkok, Thailand

Keywords:

Breast cancer, flat epithelial atypia (FEA), upgrade rate

Abstract

Objective: From previous data, pure flat epithelial atypia (FEA) of the breast demonstrated on core needle biopsy (CNB) was related to malignant upgrading. However, FEA itself is not an independent factor for developing breast cancer; therefore, the necessity of subsequent surgical excision is controversial. This study aimed to evaluate the upgrade rate of FEA after surgical excision and to demonstrate the necessity of surgical excision in FEA lesions identified on CNB.
Materials and Methods: This retrospective study involved a review of the clinical features, mammographic and ultrasound findings, and pathological reports of patients with pure FEA found from CNB specimens between January 2010 to January 2019. FEA accompanied with atypical ductal hyperplasia, atypical lobular hyperplasia, ductal carcinoma in situ (DCIS), and invasive cancer (IC) in ipsilateral breast were excluded. FEA upgrade is defined as patients with in situ or invasive cancer presented in surgical excision specimens. The breast imaging results of pure FEA and FEA upgrade subsets were compared.
Results: In total, 45 pure FEA specimens were revealed from CNB; of which, 6 of the pure FEA (13.33%) did not undergo further surgical excision, however, they showed no recurrence during follow-up (median follow-up time: 2.68 years). The majority of FEA cases were detected by mammography in 39 patients (86.67%). Of the 45 patients, 32 were classified into BI-RADS 4B (71.11%), 11 as BI-RADS 4A (24.44%), and 2 as BI-RADS 4C (4.44%). One patient was upgraded to DCIS (2.7%). BI-RADS classification did not differ between upgrade FEA and non-upgrade FEA groups (p=0.49).
Conclusion: Only a 2.7% upgrade rate, omitting the surgical excision of pure FEA from CNB, was possible. Even though our study could not demonstrate a correlation between FEA upgrade and radiological findings, BIRADS 4A was less likely to carry the malignant cells. Furthermore, segmental microcalcification tended to be associated with upgraded lesions, but not significantly.

Downloads

Published

01-11-2021

How to Cite

Numprasit, W., Samarnthai, N., & Srianuchat, T. (2021). Pure Flat Epithelial Atypia of the Breast on Core Needle Biopsy: No Need for Surgical Excision. Siriraj Medical Journal, 73(11), 727–731. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/247116

Issue

Vol. 73 No. 11 (2021): November (Special Issue; Surgery)

Section

Original Article

License

Users are free to share, copy, and redistribute all articles published in the Siriraj Medical Journal (SMJ) in any medium or format as long as you follow the following terms:

  • Attribution — You must give appropriate credit, provide a link to the material, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the publisher endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.