What Do We Know About Lymphedema? Review Article

Main Article Content

Atthawit Mongkronwong
http://orcid.org/0000-0001-7435-6980
Chanatip Nilkarn
Nutthawut Akaranuchat
http://orcid.org/0000-0003-1798-8484

Abstract

Lymphedema can cause by a congenital anomaly, an infectious disease, chronic inflammation, connective tissue disease, and cancer. The most common presenting symptoms are swelling of the affected limb, difficulty wearing clothes, and disturbances to daily life activities. Most of the time, patients have a high chance of developing a soft tissue infection that will jeopardize the quality of their life and socioeconomic status. As to management of the disease, it necessary to make a precise diagnosis and clinico-pathological staging in order to guide the treatment plan and yield optimum results. Currently, surgical management for lymphedema is based on the use of 1) physiological treatment, and 2) reductive or ablative procedures. Conservative treatment (especially for complete decongestive therapy) is still the mainstay for the management of lymphedema.

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How to Cite
Mongkronwong, A. ., Nilkarn, C. ., & Akaranuchat, N. (2021). What Do We Know About Lymphedema? Review Article. Siriraj Medical Journal, 73(5), 293–304. https://doi.org/10.33192/Smj.2021.39
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Review Article

References

1. Grada AA, Phillips TJ. Lymphedema: Pathophysiology and clinical manifestations. Journal of the American Academy of Dermatology. 2017;77(6):1009-20.
2. Suami H, Pan WR, Taylor GI. Changes in the lymph structure of the upper limb after axillary dissection: radiographic and anatomical study in a human cadaver. Plastic and reconstructive surgery. 2007;120(4):982-91.
3. Barak Mehrara M. Clinical staging and conservative management of peripheral lymphedema Wolters Kluwer: Uptodate; 2019 [Available from: http://www.uptodate.com.
4. Ramaiah KD, Ottesen EA. Progress and impact of 13 years of the global programme to eliminate lymphatic filariasis on reducing the burden of filarial disease. PLoS neglected tropical diseases. 2014;8(11):e3319.
5. Brayton KM, Hirsch AT, PJ OB, Cheville A, Karaca-Mandic P, Rockson SG. Lymphedema prevalence and treatment benefits in cancer: impact of a therapeutic intervention on health outcomes and costs. PloS one. 2014;9(12):e114597.
6. DiSipio T, Rye S, Newman B, Hayes S. Incidence of unilateral arm lymphoedema after breast cancer: a systematic review and meta-analysis. The Lancet Oncology. 2013;14(6):500-15.
7. Cormier JN, Askew RL, Mungovan KS, Xing Y, Ross MI, Armer JM. Lymphedema beyond breast cancer: a systematic review and meta-analysis of cancer-related secondary lymphedema. Cancer. 2010;116(22):5138-49.
8. Erickson VS, Pearson ML, Ganz PA, Adams J, Kahn KL. Arm edema in breast cancer patients. Journal of the National Cancer Institute. 2001;93(2):96-111.
9. Shaw C, Mortimer P, Judd PA. A randomized controlled trial of weight reduction as a treatment for breast cancer-related lymphedema. Cancer. 2007;110(8):1868-74.
10. Helyer LK, Varnic M, Le LW, Leong W, McCready D. Obesity is a risk factor for developing postoperative lymphedema in breast cancer patients. The breast journal. 2010;16(1):48-54.
11. Taylor R, Jayasinghe UW, Koelmeyer L, Ung O, Boyages J. Reliability and Validity of Arm Volume Measurements for Assessment of Lymphedema. Physical Therapy. 2006;86(2):205-14.
12. Maclellan RA, Zurakowski D, Voss S, Greene AK. Correlation Between Lymphedema Disease Severity and Lymphoscintigraphic Findings: A Clinical-Radiologic Study. Journal of the American College of Surgeons. 2017;225(3):366-70.
13. Szuba A, Shin WS, Strauss HW, Rockson S. The third circulation: radionuclide lymphoscintigraphy in the evaluation of lymphedema. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2003;44(1):43-57.
14. Hassanein AH, Maclellan RA, Grant FD, Greene AK. Diagnostic Accuracy of Lymphoscintigraphy for Lymphedema and Analysis of False-Negative Tests. Plastic and reconstructive surgery Global open. 2017;5(7):e1396.
15. Narushima M, Yamamoto T, Ogata F, Yoshimatsu H, Mihara M, Koshima I. Indocyanine Green Lymphography Findings in Limb Lymphedema. Journal of reconstructive microsurgery. 2016;32(1):72-9.
16. lymphology Tiso. The diagnosis and treatment of peripheral lymphedema. 2016:170-84.
17. Schmitz KH, Ahmed RL, Troxel AB, Cheville A, Lewis-Grant L, Smith R, et al. Weight Lifting for Women at Risk for Breast Cancer–Related Lymphedema: A Randomized Trial. JAMA. 2010;304(24):2699-705.
18. Schmitz KH, Ahmed RL, Troxel A, Cheville A, Smith R, Lewis-Grant L, et al. Weight Lifting in Women with Breast-Cancer–Related Lymphedema. New England Journal of Medicine. 2009;361(7):664-73.
19. Lawenda BD, Mondry TE, Johnstone PA. Lymphedema: a primer on the identification and management of a chronic condition in oncologic treatment. CA: a cancer journal for clinicians. 2009;59(1):8-24.
20. Casley-Smith JR, Morgan RG, Piller NB. Treatment of Lymphedema of the Arms and Legs with 5,6-Benzo-[alpha]-pyrone. New England Journal of Medicine. 1993;329(16):1158-63.
21. Loprinzi CL, Kugler JW, Sloan JA, Rooke TW, Quella SK, Novotny P, et al. Lack of Effect of Coumarin in Women with Lymphedema after Treatment for Breast Cancer. New England Journal of Medicine. 1999;340(5):346-50.
22. Carati CJ, Anderson SN, Gannon BJ, Piller NB. Treatment of postmastectomy lymphedema with low-level laser therapy: a double blind, placebo-controlled trial. Cancer. 2003;98(6):1114-22.
23. Kozanoglu E, Basaran S, Paydas S, Sarpel T. Efficacy of pneumatic compression and low-level laser therapy in the treatment of postmastectomy lymphoedema: a randomized controlled trial. Clinical Rehabilitation. 2009;23(2):117-124
24. The Diagnosis and Treatment of Peripheral Lymphedema: 2016 Consensus Document of the International Society of Lymphology. Lymphology. 2016;49(4):170-84.
25. Karri V, Yang MC, Lee IJ, Chen SH, Hong JP, Xu ES, et al. Optimizing outcome of charles procedure for chronic lower extremity lymphoedema. Annals of plastic surgery. 2011;66(4):393-402.
26. Brorson H. Liposuction in arm lymphedema treatment. Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society. 2003;92(4):287-95.
27. Chang DW. Lymphaticovenular bypass for lymphedema management in breast cancer patients: a prospective study. Plastic and reconstructive surgery. 2010;126(3):752-8.
28. Gillies H, Fraser FR. TREATMENT OF LYMPHOEDEMA BY PLASTIC OPERATION: (A PRELIMINARY REPORT). British medical journal. 1935;1(3863):96-8.
29. Goldsmith HS. Long term evaluation of omental transposition for chronic lymphedema. Annals of surgery. 1974;180(6):847-9.
30. Baumeister RG, Siuda S. Treatment of lymphedemas by microsurgical lymphatic grafting: what is proved? Plastic and reconstructive surgery. 1990;85(1):64-74; discussion 5-6.
31. Campisi C. Use of autologous interposition vein graft in management of lymphedema: preliminary experimental and clinical observations. Lymphology. 1991;24(2):71-6.
32. Koshima I, Inagawa K, Urushibara K, Moriguchi T. Supermicrosurgical lymphaticovenular anastomosis for the treatment of lymphedema in the upper extremities. Journal of reconstructive microsurgery. 2000;16(6):437-42.
33. Chang DW, Suami H, Skoracki R. A prospective analysis of 100 consecutive lymphovenous bypass cases for treatment of extremity lymphedema. Plastic and reconstructive surgery. 2013;132(5):1305-14.
34. Torrisi JS, Joseph WJ, Ghanta S, Cuzzone DA, Albano NJ, Savetsky IL, et al. Lymphaticovenous bypass decreases pathologic skin changes in upper extremity breast cancer-related lymphedema. Lymphatic research and biology. 2015;13(1):46-53.
35. Thompson N. Surgical treatment of chronic lymphoedema of the lower limb. With preliminary report of new operation. British medical journal. 1962;2(5319):1566-73.
36. Becker C, Assouad J, Riquet M, Hidden G. Postmastectomy lymphedema: long-term results following microsurgical lymph node transplantation. Annals of surgery. 2006;243(3):313-5.
37. Saaristo AM, Niemi TS, Viitanen TP, Tervala TV, Hartiala P, Suominen EA. Microvascular Breast Reconstruction and Lymph Node Transfer for Postmastectomy Lymphedema Patients. Annals of surgery. 2012;255(3):468-73.
38. Borman P. Lymphedema diagnosis, treatment, and follow-up from the view point of physical medicine and rehabilitation specialists. Turk J Phys Med Rehabil. 2018 Sep 3;64(3):179-197. doi: 10.5606/tftrd.2018.3539. PMID: 31453511; PMCID: PMC6657795.
39. Kayıran O, De La Cruz C, Tane K, Soran A. Lymphedema: From diagnosis to treatment. Turk J Surg. 2017 Jun 1;33(2):51-57. doi: 10.5152/turkjsurg.2017.3870. PMID: 28740950; PMCID: PMC5508242.