Changes in HbA2 Levels May Signify Hemoglobin Defects in Infants

Pinyaphat  Khamphikham; Manoo  Punyamung; Sakorn  Pornprasert

doi:10.33192/Smj.2021.46

Changes in HbA2 Levels May Signify Hemoglobin Defects in Infants

Authors

Pinyaphat Khamphikham Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand
Manoo Punyamung Clinical Service Center, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Sakorn Pornprasert Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand

DOI:

https://doi.org/10.33192/Smj.2021.46

Keywords:

Hemoglobin, Thalassemia, Infant

Abstract

References

1. Akhavan-Niaki H, Youssefi Kamangari R, Banihashemi A, Kholghi Oskooei V, Azizi M, Tamaddoni A, et al. Hematologic features of alpha thalassemia carriers. Int J Mol Cell Med. 2012;1(3):162-7.
2. Fucharoen G, Sanchaisuriya K, Sae-ung N, Dangwibul S, Fucharoen S. A simplified screening strategy for thalassaemia and haemoglobin E in rural communities in south-east Asia. Bull World Health Organ. 2004;82(5):364-72.
3. Sanchaisuriya K, Fucharoen S, Fucharoen G, Ratanasiri T, Sanchaisuriya P, Changtrakul Y, et al. A reliable screening protocol for thalassemia and hemoglobinopathies in pregnancy: an alternative approach to electronic blood cell counting. Am J Clin Pathol. 2005;123(1):113-8.
4. Karnpean R, Fucharoen G, Pansuwan A, Changtrakul D, Fucharoen S. A proficiency testing program of hemoglobin analysis in prevention and control of severe hemoglobinopathies in Thailand. Clin Chem Lab Med. 2013;51(6):1265-71.
5. Liu YT, Old JM, Miles K, Fisher CA, Weatherall DJ, Clegg JB. Rapid detection of alpha-thalassaemia deletions and alpha-globin gene triplication by multiplex polymerase chain reactions. Br J Haematol. 2000;108(2):295-9.
6. Pornprasert S, Wiengkum T, Srithep S, Chainoi I, Singboottra P, Wongwiwatthananukit S. Detection of alpha-thalassemia-1 Southeast Asian and Thai type deletions and beta-thalassemia 3.5-kb deletion by single-tube multiplex real-time PCR with SYBR Green1 and high-resolution melting analysis. Korean J Lab Med. 2011;31(3):138-42.
7. Yamsri S, Sanchaisuriya K, Fucharoen G, Sae-Ung N, Fucharoen S. Genotype and phenotype characterizations in a large cohort of beta-thalassemia heterozygote with different forms of alpha-thalassemia in northeast Thailand. Blood Cells Mol Dis. 2011;47(2):120-4.
8. Sae-ung N, Srivorakun H, Fucharoen G, Yamsri S, Sanchaisuriya K, Fucharoen S. Phenotypic expression of hemoglobins A(2), E and F in various hemoglobin E related disorders. Blood Cells Mol Dis. 2012;48(1):11-6.
9. Kingchaiyaphum B, Sanchaisuriya K, Fucharoen G, Chaibunruang A, Hess SY, Hinnouho GM, et al. Hemoglobins F, A2 , and E levels in Laotian children aged 6-23 months with Hb E disorders: Effect of age, sex, and thalassemia types. Int J Lab Hematol. 2020;42(3):277-83.
10. Winichagoon P, Svasti S, Winichagoon P, Chitchumroonchokchai C, Fucharoen S. Expression of betaE and gamma-globin genes in infants heterozygous for hemoglobin E and double heterozygous for hemoglobin E and alpha-thalassemia. Haematologica. 2007;92(5):702-3.

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Published

01-08-2021

How to Cite

Khamphikham, P. ., Punyamung, M. ., & Pornprasert, S. . (2021). Changes in HbA2 Levels May Signify Hemoglobin Defects in Infants. Siriraj Medical Journal, 73(5), 354–356. https://doi.org/10.33192/Smj.2021.46

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Issue

Vol. 73 No. 5 (2021): May

Section

Letter to the Editor

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