Factors Associated with Severe Lower Respiratory Tract Infection from Respiratory Syncytial Virus (RSV) in Thai Children

Atipotsawee  Tungsupreechameth; Klaita  Srisingh

doi:10.33192/Smj.2021.105

Authors

Atipotsawee Tungsupreechameth Department of Pediatrics, Faculty of Medicine, Naresuan University, Phitsanulok 65000, Thailand.
Klaita Srisingh Department of Pediatrics, Faculty of Medicine, Naresuan University, Phitsanulok 65000, Thailand.

DOI:

https://doi.org/10.33192/Smj.2021.105

Keywords:

Lower respiratory tract infections, respiratory syncytial virus, risk factor

Abstract

Objective: To determine the factors associated with severe ALRTI from RSV in children.
Materials and Methods: A retrospective study of children aged 1-60 months were conducted from 2014 to 2018. Out of 269 patients diagnosed with RSV ALRTI, 100 children were enrolled in the study, 20 had severe RSV ALRTI, while 80 had non-severe RSV ALRTI as identified by the ReSVinet scale. A multivariable logistic model was conducted to select significant variables.
Results: During the study period, 269 patients were diagnosed with RSV ALRTI. Mean age was 10.45 ± 3.53 months. Clinical manifestations of severe RSV ALRTI group had significant difference in abnormal general condition (P < 0.001), tachypnea (P < 0.001), SpO2 < 85% (P < 0.001), poor air entry in lungs (P < 0.001), and retraction (P < 0.001). The factors associated with severe RSV ALRTI group, were underlying congenital heart disease [aOR
32.45; 95% CI 3.38-311.87, P = 0.003] and duration of hospital stay >5 days [aOR 19.56; 95% CI 1.81-212.05, P = 0.014].
Conclusion: Factors associated with severe RSV ALRTI in children were underlying congenital heart disease and
duration of hospital stay >5 days.

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