Effectiveness of Ayurved Siriraj Prasa-Nam-Nom Recipe on Breast Milk Volume in Early Postpartum Women: A Randomized, Double-Blind, Placebo- Controlled Trial

Pharuhas  Chanprapaph; Chantanat  Thippayacharoentam; Apirada  Iam-am; Natchagorn  Lumlerdkij; Pravit  Akarasereenont; Tawee  Laohapand; Sudarat  Bangkha; Nhupat  Kumleemak; Sudarat  Piyophirapong; Akarin  Nimmannit; Thapthep  Thippayacharoentam

doi:10.33192/Smj.2022.2

Authors

Pharuhas Chanprapaph Breastfeeding Division, Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital, Mahidol University
Chantanat Thippayacharoentam Center of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University
Apirada Iam-am Center of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University
Natchagorn Lumlerdkij Center of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University
Pravit Akarasereenont Center of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University
Tawee Laohapand Center of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University
Sudarat Bangkha Obstetric and Gynaecological Nursing Unit, Siriraj Hospital, Mahidol University
Nhupat Kumleemak Obstetric and Gynaecological Nursing Unit, Siriraj Hospital, Mahidol University
Sudarat Piyophirapong Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University
Akarin Nimmannit Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University
Thapthep Thippayacharoentam Center of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University

DOI:

https://doi.org/10.33192/Smj.2022.2

Keywords:

Creamatocrit, galactagogue, prolactin, inadequate breast milk volume, Prasa-nam-nom

Abstract

Objective: To explore the effectiveness of Ayurved Siriraj Prasa-Nam-Nom (ASPNN) recipe on breast milk production in early postpartum women.

Methods: Fifty-four normal vaginal term delivery mothers who had inadequate milk volume were enrolled into this randomized, double-blind, placebo-controlled trial. All participants received ASPNN or placebo 1,500 mg three times/day for 3 days in the hospital and 7 days at home. Primary outcomes, including breast milk volume, %creamatocrit, and level of prolactin, were evaluated on day 1 and day 3. Satisfaction scores, adverse effects, and types of breastfeeding were also determined.

Results: On day 3, milk volume was increased in both groups. The median volume of ASPNN group was 19 ml, while that of the placebo group was 30 ml. The median %creamatocrit of ASPNN and placebo group were 7.17% and 6.98%, respectively. Mean serum prolactin levels of ASPNN and placebo group were 321.76 + 114.23 ng/ml and 323.78 + 116.68 ng/ml, respectively. Although the effects were not difference from the placebo, the reduction of prolactin in ASPNN was lower. Minor adverse effects included skin rash and mild diarrhea. Exclusive breastfeeding rate on day 11 in ASPNN and placebo group were 92.6 % and 88.5%, respectively.

Conclusion: Short term ASPNN supplementation produce no direct effect on breast milk volume, creamatocrit, and serum prolactin. It was safe and might help maintaining serum prolactin. A future trial with more participants and longer period should be conducted to confirm the effect of ASPNN on breast milk quantity and quality.

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