Effectiveness of the Four-Frequency Protocol of Repetitive Peripheral Magnetic Stimulation (rPMS) for Chronic Pain
DOI:
https://doi.org/10.33192/Smj.2022.62Keywords:
Chronic pain; neuromodulation, neuropathic pain, repetitive peripheral magnetic stimulationAbstract
Objective: Repetitive peripheral magnetic stimulation (rPMS) is a noninvasive method of delivering a magnetic field to the periphery other than the brain. The treatment has shown positive outcomes for chronic pain and provides many advantages. This study investigated the effectiveness of the four-frequency protocol of rPMS in patients with chronic pain.
Materials and Methods: A retrospective review was conducted of patients with chronic pain treated with the four-frequency protocol. Data on patient demographics, pain characteristics, quality of life, and satisfaction were collected and analyzed.
Results: Forty-eight patients (174 sessions) were eligible for analysis. Most patients (81%) were diagnosed with chronic neuropathic pain. Upon completing the 4-week course of treatment, the mean � SD of percentage of pain reduction was 49.7% � 34.8%. The pain score also significantly decreased from baseline (mean difference, 3.3; 95% CI, 2.5�4.1; P < 0.001). Responses to treatment were observed for most patients (79.2%) and most treatment sessions (87.4%). For immediate effectiveness, the mean � SD of percentage of pain reduction at the end of each treatment session was 46.2% � 27.6%. Improvements in mood, function, and sleep were reported by 75.8%, 77.3%, and 79.5% of patients, respectively. Furthermore, most patients (72.5%) expressed satisfaction with the treatment.
Conclusion: The four-frequency protocol of rPMS for patients with chronic pain significantly reduced their pain scores for immediate effect and after the 4-week treatment course. A positive treatment response, an improved quality of life, and satisfaction with the therapy were found for nearly 80% of the patients.
References
Leadley RM, Armstrong N, Reid KJ, Allen A, Misso KV, Kleijnen J. Healthy aging in relation to chronic pain and quality of life in Europe. Pain Pract. 2014;14(6):547-58.
Euasobhon P, Rushatamukayanunt P, Mandee S, Kaisrita S, Chourchart P, Chinthammit C, et al. Incidence and Treatment Strategies of Neuropathic Pain: the Tertiary Care Setting’s Experience. Siriraj Med J. 2013;65:123-7.
Faraday M. Experimental Researches in Electricity. London: Taylor and Francis; 1839.
Barker AT, Jalinous R, Freeston IL. Non-invasive magnetic stimulation of human motor cortex. Lancet. 1985;1(8437):1106-7.
Barker AT. An introduction to the basic principles of magnetic nerve stimulation. J Clin Neurophysiol. 1991;8(1):26-37.
Khedr EM, Ahmed MA, Alkady EA, Mostafa MG, Said HG. Therapeutic effects of peripheral magnetic stimulation on traumatic brachial plexopathy: clinical and neurophysiological study. Neurophysiol Clin. 2012;42(3):111-8.
Leung A, Fallah A, Shukla S. Transcutaneous magnetic stimulation (TMS) in alleviating post-traumatic peripheral neuropathic pain States: a case series. Pain Med. 2014;15(7):1196-9.
Pujol J, Pascual-Leone A, Dolz C, Delgado E, Dolz JL, Aldomà J. The effect of repetitive magnetic stimulation on localized musculoskeletal pain. Neuroreport. 1998;9(8):1745-8.
Smania N, Corato E, Fiaschi A, Pietropoli P, Aglioti SM, Tinazzi M. Therapeutic effects of peripheral repetitive magnetic stimulation on myofascial pain syndrome. Clin Neurophysiol. 2003;114(2):350-8.
Smania N, Corato E, Fiaschi A, Pietropoli P, Aglioti SM, Tinazzi M. Repetitive magnetic stimulation: a novel therapeutic approach for myofascial pain syndrome. J Neurol. 2005;252(3):307-14.
Lo YL, Fook-Chong S, Huerto AP, George JM. A randomized, placebo-controlled trial of repetitive spinal magnetic stimulation in lumbosacral spondylotic pain. Pain Med. 2011;12(7):1041-5.
Massé-Alarie H, Flamand VH, Moffet H, Schneider C. Peripheral neurostimulation and specific motor training of deep abdominal muscles improve posturomotor control in chronic low back pain. Clin J Pain. 2013;29(9):814-23.
Massé-Alarie H, Beaulieu LD, Preuss R, Schneider C. Repetitive peripheral magnetic neurostimulation of multifidus muscles combined with motor training influences spine motor control and chronic low back pain. Clin Neurophysiol. 2017;128(3):442-53.
Beaulieu LD, Schneider C. Repetitive peripheral magnetic stimulation to reduce pain or improve sensorimotor impairments: A literature review on parameters of application and afferents recruitment. Neurophysiol Clin. 2015;45(3):223-37.
Rossi S, Hallett M, Rossini PM, Pascual-Leone A. Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. Clin Neurophysiol. 2009;120(12):2008-39.
Maccabee PJ, Amassian VE, Cracco RQ, Cracco JB, Eberle L, Rudell A. Stimulation of the human nervous system using the magnetic coil. J Clin Neurophysiol. 1991;8(1):38-55.
Cruccu G, Garcia-Larrea L, Hansson P, Keindl M, Lefaucheur JP, Paulus W, et al. EAN guidelines on central neurostimulation therapy in chronic pain conditions. Eur J Neurol. 2016;23(10):1489-99.
Suzuki H, Aono S, Inoue S, Imajo Y, Nishida N, Funaba M, et al. Clinically significant changes in pain along the Pain Intensity Numerical Rating Scale in patients with chronic low back pain. PLoS ONE. 2020;15(3):e0229228.
Wilson EB. Probable Inference, the Law of Succession, and Statistical Inference. JASA. 1927;22(158):209-12.
Behrens M, Mau-Möller A, Zschorlich V, Bruhn S. Repetitive peripheral magnetic stimulation (15 Hz RPMS) of the human soleus muscle did not affect spinal excitability. J Sports Sci Med. 2011;10(1):39-44.
Machetanz J, Bischoff C, Pichlmeier R, Riescher H, Meyer BU, Sader A, et al. Magnetically induced muscle contraction is caused by motor nerve stimulation and not by direct muscle activation. Muscle Nerve. 1994;17(10):1170-5.
Zhu Y, Starr A, Haldeman S, Fu H, Liu J, Wu P. Magnetic stimulation of muscle evokes cerebral potentials by direct activation of nerve afferents: a study during muscle paralysis. Muscle Nerve. 1996;19(12):1570-5.
Beaulieu LD, Schneider C. Effects of repetitive peripheral magnetic stimulation on normal or impaired motor control. A review. Neurophysiol Clin. 2013;43(4):251-60.
Heldmann B, Kerkhoff G, Struppler A, Havel P, Jahn T. Repetitive peripheral magnetic stimulation alleviates tactile extinction. Neuroreport. 2000;11(14):3193-8.
Kerkhoff G, Heldmann B, Struppler A, Havel P, Jahn T. The effects of magnetic stimulation and attentional cueing on tactile extinction. Cortex. 2001;37(5):719-23.
Krause P, Straube A. Repetitive magnetic and functional electrical stimulation reduce spastic tone increase in patients with spinal cord injury. Suppl Clin Neurophysiol. 2003;56:220-5.
Lim YH, Song JM, Choi EH, Lee JW. Effects of repetitive peripheral magnetic stimulation on patients with acute low back pain: a pilot study. Ann Rehabil Med. 2018;42(2):229-38.
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