Chronic Myeloid Leukemia (CML) at National Referral Hospital in Indonesia

Authors

  • Wulyo Rajabto Division of Hematology-Medical Oncology, Department of Internal Medicine Dr. Cipto Mangunkusumo General Hospital/ Faculty of Medicine Universitas Indonesia Jakarta
  • Ary Harryanto Reksodiputro Division of Hematology-Medical Oncology, Department of Internal Medicine Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine Universitas Indonesia Jakarta
  • Ikhwan Rinaldi Division of Hematology-Medical Oncology, Department of Internal Medicine Dr. Cipto Mangunkusumo General Hospital/ Faculty of Medicine Universitas Indonesia Jakarta
  • Hilman Tadjoedin Division of Hematology-Medical Oncology, Department of Internal Medicine Dharmais Hospital, National Cancer Centre/ Faculty of Medicine Universitas Indonesia
  • Dimas Priantono Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta
  • Yohana Kusuma Angkasa Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta

DOI:

https://doi.org/10.33192/Smj.2022.63

Keywords:

Chronic phase chronic myeloid leukemia, epidemiology, diagnosis, treatment, monitoring

Abstract

Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of the Philadelphia chromosome and BCR-ABL fusion oncogene. CML is one of the illnesses that may be treated using Tyrosine Kinase Inhibitors (TKIs), a type of targeted therapy. Since TKIs are the standard of therapy, long-term survival of CML has improved compared to chemotherapy and interferon-alpha. For the first-line treatment for CML, there are four commercially available TKIs that serve as an integral part of the disease management. However, there are many challenges in diagnosing, treating, and monitoring patients with chronic phase CML in Indonesia. This study highlights the epidemiology data of chronic phase CML patients, particularly at Dr. Cipto Mangunkusumo General Hospital, an Indonesian national referral hospital, and how to diagnose, select first-line TKIs, and monitor the response of treatment after TKIs administration.

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Published

01-08-2022

How to Cite

Rajabto, W. ., Reksodiputro, A. H. ., Rinaldi, I. ., Tadjoedin, H. ., Priantono, D. ., & Angkasa, Y. K. . (2022). Chronic Myeloid Leukemia (CML) at National Referral Hospital in Indonesia. Siriraj Medical Journal, 74(8), 530–536. https://doi.org/10.33192/Smj.2022.63

Issue

Section

Review Article