Long-term Oncologic Outcomes After Curative Surgery in Stage I–III Thai Colorectal Cancer Patients

Aitsariya  Mongkhonsupphawan; Nutchaphol  Sethalao; Woramin  Riansuwan

doi:10.33192/Smj.2022.87

Authors

Aitsariya Mongkhonsupphawan Colorectal Surgery Unit, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
Nutchaphol Sethalao Colorectal Surgery Unit, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
Woramin Riansuwan Colorectal Surgery Unit, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok

DOI:

https://doi.org/10.33192/Smj.2022.87

Keywords:

Colorectal cancer, long-term outcomes, overall survival, disease-free survival, Asian, Thai

Abstract

Objective: The survival rate for colorectal cancer varies and there are limited reports regarding the long-term outcomes after curative treatment in Thai patients. This study aimed to determine the long-term oncologic results in non-metastatic Thai colorectal cancer patients after curative surgery.

Materials and Methods: We performed a retrospective review of a prospectively collected colorectal cancer registry. Short-term and long-term outcomes were analyzed.

Results: Six hundred and sixty two patients were included in the study, 51.9% colon cancer and 48.1% rectal cancer patients. The mean age was 63.6 ± 12.7 years. The median follow-up time was 5.4 years [IQR: 2.1–7.4]. The 5-year local recurrence was 6.4%; 3.3% in colon cancer and 9.9% in rectal cancer. The 5-year overall survival (5-yr OS) in the colon cancer patients was 76.3%; 94.6% in stage I, 80.8% in stage II, and 65.3% in stage III. The 5-yr OS in the rectal cancer patients was 65.1%; 84.7% in stage I, 75% in stage II, and 51% in stage III. The 5-year disease-free survival (5-yr DFS) in the colon cancer patients was 76.5%; 91.4% in stage I, 81.3% in stage II, and 66.4% in stage III. The 5-yr DFS in the rectal cancer patients was 63.8%; 81.5% in stage I, 75.1% in stage II, and 50.1% in stage III.

Conclusion: The long-term oncologic outcomes after curative treatments in this study were acceptable. The prognosis of treatment depends on the disease stage. Comparing stage by stage, colon cancer has a better prognosis than rectal cancer.

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