Evaluating Risk Factors for Cumulative Life Course Impairment in Psoriasis using Patient-Acceptable Symptom State and European Quality of Life 5 Dimensions (EQ-5D)

Risk Factors for CLCI in Psoriasis

Authors

  • Leena Chularojanamontri Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
  • Chanisada Wongpraparut Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
  • Narumol Silpa-archa Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
  • Chayada Chaiyabutr Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
  • Supisara Wongdama Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
  • Praveena Chiowchanwisawakit Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok

DOI:

https://doi.org/10.33192/smj.v75i9.260756

Keywords:

Cumulative life course impairment, EQ-5D, Patient-acceptable symptom state, Psoriasis, Quality of life

Abstract

Objective: To evaluated the health-utility values and risk factors for cumulative life course impairment (CLCI) using Patient Acceptable Symptom State (PASS) and European Quality of Life 5 Dimensions (EQ-5D).

Materials and Methods: This cross-sectional investigation enrolled patients with psoriasis. Patients were asked PASS questions about their overall self-perceived health state, adaptation, and expectations for current, future, and lifelong conditions. The patients also completed EQ-5D.

Results: The mean age of 139 enrolled patients was 45.8 ± 14.4 years, and 57.6% were women. Most cases had chronic plaque psoriasis 121 (87.1%). For current PASS, satisfaction was significantly associated with older age, being married, and lower disease severity. The mean health-utility value and visual analog scale of the 139 patients were 0.89 ± 0.12 and 77.0 ± 17.4, respectively. Patients would not accept their disease if they had moderate to extreme problems in usual activities and depression/anxiety for the future and lifelong. Univariate analysis revealed that depression and usual activities were significantly associated with satisfaction for current PASS, future PASS, and lifelong PASS.

Conclusion: Disease severity, age, marital status, problems with usual activities, and depression/anxiety were significantly related to CLCI. These findings may allow physicians to identify psychosocial and psychological aspects of psoriatic patients at high risk for developing CLCI. Early and adequate treatment, good coping strategies, and good social support can prevent a negative impact on CLCI and major life-changing decisions.

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Clinical characteristics and EuroQol-5 Dimension-5 Levels (EQ-5D-5L) for current Patient Acceptable Symptom State (PASS), future PASS, and lifelong PASS

Published

01-09-2023

How to Cite

Chularojanamontri, L. ., Wongpraparut, C., Silpa-archa, N., Chaiyabutr, C., Wongdama, S. ., & Chiowchanwisawakit, P. (2023). Evaluating Risk Factors for Cumulative Life Course Impairment in Psoriasis using Patient-Acceptable Symptom State and European Quality of Life 5 Dimensions (EQ-5D): Risk Factors for CLCI in Psoriasis. Siriraj Medical Journal, 75(9), 646–654. https://doi.org/10.33192/smj.v75i9.260756

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