The Effect of The Thai Herbal Wattana Formula on Platelet Aggregation and The Relationship with Innate Dhatu Chao Ruean

Suveerawan Limsuvan; Titchaphorn  Palo; Dollaporn  Mamaethong; Nut  Yuthanarat; Suksalin  Booranasubkajorn; Natchagorn  Lumlerdkij; Kamonchanok  Maneechai; Pravit  Akarasereenont

doi:10.33192/smj.v75i5.261536

Authors

Suveerawan Limsuvan Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
Titchaphorn Palo The Department of Pharmacology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok
Dollaporn Mamaethong The Center of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Nut Yuthanarat The Center of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
Suksalin Booranasubkajorn The Center of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
Natchagorn Lumlerdkij The Center of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
Kamonchanok Maneechai The Center of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
Pravit Akarasereenont The Center of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok

DOI:

https://doi.org/10.33192/smj.v75i5.261536

Keywords:

Thai Herbal Wattana formula, WNF, Herbal medicine, Platelet aggregation, innate Dhatu Chao Ruean

Abstract

Objective: To investigate the effects of the WNF on platelet aggregation and find a link between iDCR factors and platelet aggregation.

Materials and Methods: Forty healthy volunteers with different iDCRs (Earth, Water, Wind, and Fire) received a single dose of 1,000 mg WNF. A blood sample was taken before and after the WNF administration at 3, 6, and 24 hours for analysis of platelet aggregation by aggregometry. Epinephrine, adenosine diphosphate (ADP) and collagen were used as platelet agonists.

Results: The WNF affects platelet aggregation in some subjects, especially females with an Earth iDCR or Wind iDCR with hyperaggregation patterns at baseline. The result after WNF treatment revealed that the percentage of platelet aggregation significantly changed downward at 3 hours and then recovered to pre-dosing levels after 24 hours. Additionally, it also did not have any relationship to iDCR. There were no reported adverse drug events.

Conclusion: WNF should be used with caution in patients with blood diseases and a close eye should be kept on herb-drug interactions such as with aspirin or other NSAIDs.

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