Habitual Snoring in Pediatric Thalassemia Disease; Prevalence, Quality of Life and Risk Factors

Araya Satdhabudha; Chonnikarn  Parnthong; Pacharapan Surapolchai; Tasama  Pusongchai; Wallee Satayasai; Jassada Buaboonnam; Phakatip Sinlapamongkolkul

doi:10.33192/smj.v75i8.263395

Authors

Araya Satdhabudha Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathumthani
Chonnikarn Parnthong Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathumthani
Pacharapan Surapolchai Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathumthani
Tasama Pusongchai Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathumthani
Wallee Satayasai Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathumthani
Jassada Buaboonnam Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
Phakatip Sinlapamongkolkul Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathumthani

DOI:

https://doi.org/10.33192/smj.v75i8.263395

Keywords:

Habitual snoring, obstructive sleep apnea, thalassemia, OSA-18

Abstract

Objective: To compare the prevalence of HS and quality of life in non-transfusion dependent thalassemia (NTDT) and Transfusion dependent thalassemia (TDT) patients and to identify risk factors associated with HS in pediatric thalassemia.

Materials and Methods: We conducted a cross-sectional study of pediatric thalassemic patients aged from 6 months - 18 years between January 2020 and October 2020, at Thammasat University Hospital, Thailand.

Results: There were 141 thalassemia patients (35 TDT and 106 NTDT), aged 7 months-18 years, 73 (51.8%) were male. Sixty-eight patients (48.2%) reported snoring; 28 patients (19.9%) had HS; the remaining 40 patients (28.4%) had simple snoring. The prevalence of HS was not significantly different between TDT and NTDT group (6 (17.1%) VS 22 (20.8%); P= 0.527). Quality of life assessed by OSA-18 score was not significant difference between TDT and NTDT groups (51.3 ± 18.8 VS 45.7 ± 11.4; P=0.141). The associating risk factors for the development of HS after multivariate logistic analysis were nasal congestion, and male gender, with an adjusted OR of 5.3 and 3.0, respectively.

Conclusion: Prevalence of HS was increased in children with thalassemia. Factors such as nasal congestion and male gender were strongly associated with HS in this population. The quality of life assessment using the OSA-18 questionnaire indicated that thalassemia children generally exhibited a good quality of life. Additionally, our study observed relatively low serum ferritin levels in comparison to previous studies. The standard care provided for TDT patients, includes regular blood transfusion and effective iron chelation, may contribute to slowing down the degree of nasopharyngeal narrowing in thalassemia patients.

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