Acute hemolysis in glucose-6-phosphate dehydrogenase deficiency a study in 20 patients

Authors

  • Supa Na-Nakorn Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
  • Prawase Wasi Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
  • Vicharn Panich Faculty of Graduate Studies, Mahidol University
  • Munsit Sookanek Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
  • Malida Pornpatkut Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
  • Pensri Pootrakul Faculty of Medical Technology, Mahidol University

Keywords:

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Abstract

All patients were male 13 to 53 years old. 19 of them had fever; acute hemolysis occurred 2-3 or more days after administration of drugs in 15, and 4 had acute hemolysis only one day after the drug ingestion. One had diarrhea without fever and ingestion of drug preceded the acute hemolysis. 

Duration of hemoglobinuria ranged from one occasion to 8 days in 16 patients with record. Azotemia was studied in 18 patients, 14 gave positive result. In 8 cases with follow-up study of azotemia, the duration ranged from 5 days to 6 weeks. Peritoneal dialysis was done in 3. One of these 20 patients died.

The clinical and hematologic data as well as 4 examples with various clinical severity are presented in detail. 

References

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Published

28-11-2023

How to Cite

Na-Nakorn, S., Wasi, P., Panich, V., Sookanek, M., Pornpatkut, M., & Pootrakul, P. (2023). Acute hemolysis in glucose-6-phosphate dehydrogenase deficiency a study in 20 patients. Siriraj Medical Journal, 22(10), 1117–1137. Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/264550

Issue

Vol. 22 No. 10 (1970): October

Section

Original Article

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