Lung and Airway Disease Caused by E-Cigarette (Vape): A Systematic Review


  • Arya Marganda Simanjuntak Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Riau University, Arifin Achmad General Hospital, Pekanbaru, Riau, Indonesia
  • Mokhammad Raihan Eka Putra Medical School, Faculty of Medicine, Riau University, Arifin Achmad General Hospital, Pekanbaru, Riau, Indonesia
  • Nindy Putri Amalia Medical School, Faculty of Medicine, Riau University, Arifin Achmad General Hospital, Pekanbaru, Riau, Indonesia
  • Anastasya Hutapea Medical School, Faculty of Medicine, Riau University, Arifin Achmad General Hospital, Pekanbaru, Riau, Indonesia
  • Suyanto Suyanto Department of Public Health, Faculty of Medicine, Riau University, Pekanbaru, Riau, Indonesia
  • Indi Esha Siregar Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Riau University, Arifin Achmad General Hospital, Pekanbaru, Riau, Indonesia



Lung Disease, E-Cigarette, Vape


Vape use is increasing among the youth and there is a catchphrase that vape is the solution to conventional tobacco smoking. Some case reports show the impact of vape use in the form of lung injury. However, there are no studies that definitively determine how many cases and what kind of problems in the lungs and airways can be caused by the use of vape and this is the purpose of our research. This systematic review article used several databases with the keywords "Vape OR E-cigarette" and "Disease." We screened and eliminated articles based on the PEOS framework. The included articles were analyzed for risk of bias using the JBI critical appraisal tool. A total of 16 articles were included and involved 313 patients in this review. Several case reports show the incidence of pulmonary infections in vape users, lung damage (EVALI), respiratory failure, burning throat, and various other events associated with vape use. The duration of vape use also varies before the appearance of the disease and the earliest use duration is six months and the longest is up to years. Vape use poses a risk of lung and airway disease and requires further study to accurately determine the degree of risk of the impact of vape use on lung and airway health. In conclusion, vape circulation vigilance needs to be considered because the impacts can cause health issues and interfere with the achievement of health goals for all.


Rom O, Pecorelli A, Valacchi G, Reznick AZ. Are E-cigarettes a safe and good alternative to cigarette smoking? Ann N Y Acad Sci. 2015;1340:65–74.

Cullen KA, Gentzke AS, Sawdey MD, Chang JT, Anic GM, Wang TW, et al. e-Cigarette Use Among Youth in the United States, 2019. JAMA. 2019;322:2095–103.

Habib E, Helaly M, Elshaer A, Sriwi D, Ahmad MS, Mohamed MI, et al. Prevalence and perceptions of e-cigarette use among medical students in a Saudi University. J Family Med Prim Care. 2020;9:3070–5.

Simanjuntak AM, Hutapea A, Tampubolon BS, Browlim S, Napitupulu YP, Siregar IE, et al. Current Developments of Smoking and Vaping, Is Vaping Safer? Jurnal Respirasi. 2023;9:159–68.

Shi J, Dai W, Chavez J, Carreno J, Zhao L, Kleinman MT, et al. One Acute Exposure to E-Cigarette Smoke Using Various Heating Elements and Power Levels Induces Pulmonary Inflammation. Cardiol Res. 2022;13:323–32.

Drabkin MJ, Heyligers B. Vaping-associated pulmonary disease (VAPD): An unusual pattern of CT findings. Radiol Case Rep. 2020;15:154–5.

Savage E, Dehmer J. Streptococcus intermedius empyema in an adolescent with a history of vaping: A case report. J Pediatr Surg Case Rep. 2023;92:102618.

Chen L, Arens R, Chidambaram AG, Capponi S, Alshawa L, Claeys TA, et al. Vaping Associated Pulmonary Nontuberculous Mycobacteria. Lung. 2021;199:21–7.

Roman S, Millet C, Geris S, Manickam R, Mechineni A. Crazy vaping and crazy-paving, a case of E-Cigarette/Vaping-Associated Lung Injury (EVALI) with chest CT showing crazy-paving pattern. Radiol Case Rep. 2021;16:3208–12.

Fryman C, Lou B, Weber AG, Steinberg HN, Khanijo S, Iakovou A, et al. Acute Respiratory Failure Associated With Vaping. Chest. 2020;157:e63–8.

Park H-R, O’Sullivan M, Vallarino J, Shumyatcher M, Himes BE, Park J-A, et al. Transcriptomic response of primary human airway epithelial cells to flavoring chemicals in electronic cigarettes. Sci Rep. 2019;9:1400.

Alexander LEC, Bellinghausen AL, Eakin MN. What are the mechanisms underlying vaping-induced lung injury? J Clin Invest. 2020;130:2754–6.

Blount BC, Karwowski MP, Morel-Espinosa M, Rees J, Sosnoff C, Cowan E, et al. Evaluation of Bronchoalveolar Lavage Fluid from Patients in an Outbreak of E-cigarette, or Vaping, Product Use-Associated Lung Injury - 10 States, August-October 2019. MMWR Morb Mortal Wkly Rep. 2019;68:1040–1.

Clapp PW, Jaspers I. Electronic Cigarettes: Their Constituents and Potential Links to Asthma. Curr Allergy Asthma Rep. 2017;17:79.

Szafran BN, Pinkston R, Perveen Z, Ross MK, Morgan T, Paulsen DB, et al. Electronic-Cigarette Vehicles and Flavoring Affect Lung Function and Immune Responses in a Murine Model. Int J Mol Sci. 2020;21.

Lechasseur A, Altmejd S, Turgeon N, Buonanno G, Morawska L, Brunet D, et al. Variations in coil temperature/power and e‐liquid constituents change size and lung deposition of particles emitted by an electronic cigarette. Physiol Rep. 2019;7:e14093.

Smith ML, Gotway MB, Crotty Alexander LE, Hariri LP. Vaping-related lung injury. Virchows Archiv. 2021;478:81–8.

Chand HS, Muthumalage T, Maziak W, Rahman I. Pulmonary Toxicity and the Pathophysiology of Electronic Cigarette, or Vaping Product, Use Associated Lung Injury. Front Pharmacol. 2020;10.


Jonas A. Impact of vaping on respiratory health. BMJ. 2022;e065997.

Park J-A, Crotty Alexander LE, Christiani DC. Vaping and Lung Inflammation and Injury. Annu Rev Physiol. 2022;84:611–29.

Ween MP, Hamon R, Macowan MG, Thredgold L, Reynolds PN, Hodge SJ. Effects of E‐cigarette E‐liquid components on bronchial epithelial cells: Demonstration of dysfunctional efferocytosis. Respirology. 2020;25:620–8.

Kooragayalu S, El-Zarif S, Jariwala S. Vaping Associated Pulmonary Injury (VAPI) with superimposed Mycoplasma pneumoniae infection. Respir Med Case Rep. 2020;29:100997.

Massey M, Barney J. Pulmonary actinomycosis and marijuana vaping. BMJ Case Rep. 2021;14:e240973.

Chaumont M, van de Borne P, Bernard A, Van Muylem A, Deprez G, Ullmo J, et al. Fourth generation e-cigarette vaping induces transient lung inflammation and gas exchange disturbances: results from two randomized clinical trials. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2019;316:L705–19.

Aftab G, Ahmad M, Frenia D. Vaping-associated Lung Injury. Cureus. 2019;11(11):e6216.

Lin C, Arrossi V, Yadav R, Choi H. Vaping-related pulmonary granulomatous disease. Respir Med Case Rep. 2020;31:101179.

Edmonds PJ, Copeland C, Conger A, Richmond BW. Vaping-induced diffuse alveolar hemorrhage. Respir Med Case Rep. 2020;29:100996.

Grech AK, Keating DT, Garner DJ, Naughton MT. A case of extreme carboxyhaemoglominemia due to vaping. Respirol Case Rep. 2022;10.

Lucchiari C, Masiero M, Mazzocco K, Veronesi G, Maisonneuve P, Jemos C, et al. Benefits of e-cigarettes in smoking reduction and in pulmonary health among chronic smokers undergoing a lung cancer screening program at 6 months. Addictive Behaviors. 2020;103:106222.

Chaumont M, Tagliatti V, Channan EM, Colet J-M, Bernard A, Morra S, et al. Short halt in vaping modifies cardiorespiratory parameters and urine metabolome: a randomized trial. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2020;318:L331–44.



How to Cite

Simanjuntak, A. M., Putra, M. R. E., Amalia, N. P., Hutapea, A., Suyanto, S., & Siregar, I. E. (2024). Lung and Airway Disease Caused by E-Cigarette (Vape): A Systematic Review. Siriraj Medical Journal, 76(5), 325–332.



Review Article