Effective Epidural Analgesia during Labor: A Feasible Method to Decrease Unnecessary Cesarean Deliveries in Thailand

Authors

  • Saranya Lertkovit Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Clinical Research Fellow, Division of Obstetric Anesthesia, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical School, Massachusetts, United States of America
  • William R. Camann Director Emeritus, Division of Obstetric Anesthesia, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Associate Professor of Anesthesia, Harvard Medical School, Boston, Massachusetts, United States of America

DOI:

https://doi.org/10.33192/smj.v76i8.268247

Keywords:

cesarean delivery, labor pain, neuraxial labor analgesia, obstetric anesthesiologists

Abstract

Thailand has reported a high rate of cesarean delivery (45%–55%), prompting global concern about an increase in cesarean delivery rates. Fear of labor pains is one of the most common reasons pregnant women opt for cesarean delivery. Labor pain is associated with cervix dilation and fetal descent into the birth canal, which is exacerbated by ischemic pain caused by uterine contraction. Modern medical and non-medical techniques have demonstrated efficacy in reducing pain and ensuring safety during labor and delivery. Neuraxial labor analgesia is a highly effective medical pain relief method but has no effect on the rate of cesarean or assisted vaginal delivery. Medication administration for pain relief during labor, using a combination of a local anesthetic and an opioid, was observed to be transmitted across the placenta to the fetus, but had no significant effects on fetal outcomes in mothers who chose epidural analgesia. There are several techniques for administering neuraxial labor analgesia that can be customized for each pregnant woman. To achieve the most wonderful feasible labor and delivery experience, effective epidural labor analgesia is a crucial technique for reducing anxiety and suffering about labor pain. It is safe, widely used world-wide, and effective. Implementing a policy to increase public and medical providers awareness and acceptance of labor pain relief, as well as establishing a safe obstetric anesthesia service provided by obstetric anesthesiologists, could improve maternal and neonatal safety while significantly lowering the rate of unnecessary cesarean deliveries.

Author Biography

William R. Camann, Director Emeritus, Division of Obstetric Anesthesia, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Associate Professor of Anesthesia, Harvard Medical School, Boston, Massachusetts, United States of America

Director, Emeritus, Obstetric Anesthesiology

Brigham and Women’s Hospital

Associate Professor of Anesthesia Harvard Medical School

References

Caughey AB, Cahill AG, Guise JM, Rouse DJ. Safe prevention of the primary cesarean delivery. Am J Obstet Gynecol. 2014;210(3):179-93.

Betran AP, Torloni MR, Zhang JJ, Gulmezoglu AM, WHO working group on caesarean section. WHO statement on caesarean section rates. BJOG. 2016;123(5):667-70.

Sukmanee J, Liabsuetrakul T, Peeyananjarassri K. Rates and indications of cesarean section using the Robson classification in a university hospital in southern thailand 2014-2016. Journal of Health Science and Medical Research. 2020;38(4):307-19.

Anekpornwattana S, Yangnoi J, Jareemit N, Borriboonhiransan D. Cesarean section rate in siriraj hospital according to the Robson classification. Thai Journal of Obstetrics and Gynaecology. 2020;28(1):6-15.

Liabsuetrakul T, Sukmanee J, Thungthong J, Lumbiganon P. Trend of cesarean section rates and correlations with adverse maternal and neonatal outcomes: a secondary analysis of thai universal coverage scheme data. AJP Rep. 2019;9(4):e328-e36.

Suwanrath C, Chunuan S, Matemanosak P, Pinjaroen S. Why do pregnant women prefer cesarean birth? a qualitative study in a tertiary care center in southern thailand. BMC Pregnancy and Childbirth. 2021;21(1):23.

Nuampa S, Ratinthorn A, Lumbiganon P, Rungreangkulkij S, Rujiraprasert N, Buaboon N, et al. "Because it eases my childbirth plan": a qualitative study on factors contributing to preferences for caesarean section in thailand. BMC Pregnancy Childbirth. 2023;23(1):280.

Matemanosak P, Suwanrath C. Knowledge and attitudes of pregnant thai women regarding modes of birth: a hospital-based study in southern thailand. The Open Public Health Journal. 2021.

Paoin P, Prasongvej P, Chanthasenanont A, Niumpradit T, Pongrojpaw D, Suwannarurk K. Efficacy of Music Therapy and Zingiber officinale Roscoe Aromatherapy for Reducing Pain during the First Stage of Labor: A Randomized Controlled Trial . Siriraj Med J. 2023;75(10):707-12.

ACOG committee opinion. No. 339: Analgesia and cesarean delivery rates. Obstet Gynecol. 2006;107(6):1487-8.

ACOG Practice Bulletin No. 209: Obstetric analgesia and anesthesia. Obstet Gynecol. 2019;133(3):e208-e25.

Hu LQ, Flood P, Li Y, Tao W, Zhao P, Xia Y, et al. No pain labor & delivery: a global health initiative's impact on clinical outcomes in china. Anesth Analg. 2016;122(6):1931-8.

Drzymalski DM, Guo JC, Qi XQ, Tsen LC, Sun Y, Ouanes JP, et al. The effect of the no pain labor & delivery-global health initiative on cesarean delivery and neonatal outcomes in china: an interrupted time-series analysis. Anesth Analg. 2021;132(3):698-706.

Pan PH, Eisenach JC. The pain of childbirth and its effect on the mother and the fetus. In: Chestnut DH, Wong CA, Tsen LC, Ngan Kee WD, Beilin Y, Mhyre JM, et al., editors. Chestnut’s obstetric anesthesia. 5th ed. Philadelphia: Elsevier Inc; 2014. p. 413-26.

Eltzschig HK, Lieberman ES, Camann WR. Regional anesthesia and analgesia for labor and delivery. N Engl J Med. 2003;348(4):319-32.

Campbell DC, Camann WR, Datta S. The addition of bupivacaine to intrathecal sufentanil for labor analgesia. Anesth Analg. 1995;81(2):305-9.

Simmons SW, Taghizadeh N, Dennis AT, Hughes D, Cyna AM. Combined spinal-epidural versus epidural analgesia in labour. Cochrane Database Syst Rev. 2012;10(10):Cd003401.

Wong CA. Epidural and spinal analgesia /anesthesia for labor and vaginal delivery. In: Chestnut DH, Wong CA, Tsen LC, Ngan Kee WD, Beilin Y, Mhyre JM, et al., editors. Chestnut’s obstetric anesthesia. 5th ed. Philadelphia: Elsevier Inc; 2014. p. 460-508.

Chau A, Tsen L. Neuraxial labor analgesia: initiation techniques. Best Pract Res Clin Anaesthesiol. 2022;36(1):3-15.

Camann W, Abouleish A, Eisenach J, Hood D, Datta S. Intrathecal sufentanil and epidural bupivacaine for labor analgesia: dose-response of individual agents and in combination. Reg Anesth Pain Med. 1998;23(5):457-62.

Lim G, Facco FL, Nathan N, Waters JH, Wong CA, Eltzschig HK. A Review of the Impact of obstetric anesthesia on maternal and neonatal outcomes. Anesthesiology. 2018;129(1):192-215.

Carvalho B, George RB, Cobb B, McKenzie C, Riley ET. Implementation of programmed intermittent epidural bolus for the maintenance of labor analgesia. Anesth Analg. 2016;123(4):965-71.

First and Second Stage Labor Management: ACOG clinical practice guideline no. 8. Obstet Gynecol. 2024;143(1):144-62.

Abouleish A, Abouleish E, Camann W. Combined spinal-epidural analgesia in advanced labour. Can J Anaesth. 1994;41(7):575-8.

Cheng SL, Bautista D, Leo S, Sia TH. Factors affecting fetal bradycardia following combined spinal epidural for labor analgesia: a matched case-control study. J Anesth. 2013;27(2):169-74.

Yang L, Wan L, Huang H, Qi X. Uterine hypertonus and fetal bradycardia occurred after combined spinal-epidural analgesia during induction of labor with oxytocin infusion: A case report. Medicine (Baltimore). 2019;98(28):e16282.

Heesen M, Rijs K, Rossaint R, Klimek M. Dural puncture epidural versus conventional epidural block for labor analgesia: a systematic review of randomized controlled trials. Int J Obstet Anesth. 2019;40:24-31.

Chau A, Bibbo C, Huang CC, Elterman KG, Cappiello EC, Robinson JN, et al. Dural puncture epidural technique improves labor analgesia quality with fewer side effects compared with epidural and combined spinal epidural techniques: a randomized clinical trial. Anesth Analg. 2017;124(2):560-9.

Bakhet WZ. A randomized comparison of epidural, dural puncture epidural, and combined spinal-epidural without intrathecal opioids for labor analgesia. J Anaesthesiol Clin Pharmacol. 2021;37(2):231-6.

Maeda A, Villela-Franyutti D, Lumbreras-Marquez MI, Murthy A, Fields KG, Justice S, et al. Labor analgesia initiation with dural puncture epidural versus conventional epidural techniques: a randomized biased-coin sequential allocation trial to determine the effective dose for 90% of patients of bupivacaine. Anesth Analg. 2024;138(6):1205-14.

Anim-Somuah M, Smyth RM, Jones L. Epidural versus non-epidural or no analgesia in labour. Cochrane Database Syst Rev. 2011(12):CD000331.

Leighton BL, Halpern SH. Epidural analgesia: effects on labor progress and maternal and neonatal outcome. Semin Perinatol. 2002;26(2):122-35.

Abhirami GR, Sathyavani C, George CE. The effect of epidural analgesia on the maternal and fetal outcomes in mothers undergoing induction of labour. J Obstet Gynaecol India. 2022;72(Suppl 1):174-9.

Antonakou A, Papoutsis D. The effect of epidural analgesia on the delivery outcome of induced labour: a retrospective case series. Obstet Gynecol Int. 2016;2016:5740534.

Chen SY, Lin PL, Yang YH, Yang YM, Lee CN, Fan SZ, et al. The effects of different epidural analgesia formulas on labor and mode of delivery in nulliparous women. Taiwan J Obstet Gynecol. 2014;53(1):8-11.

Wong CA, Scavone BM, Peaceman AM, McCarthy RJ, Sullivan JT, Diaz NT, et al. The risk of cesarean delivery with neuraxial analgesia given early versus late in labor. N Engl J Med. 2005;352(7):655-65.

Sng BL, Leong WL, Zeng Y, Siddiqui FJ, Assam PN, Lim Y, et al. Early versus late initiation of epidural analgesia for labour. Cochrane Database Syst Rev. 2014;2014(10):CD007238.

Liu EH, Sia AT. Rates of caesarean section and instrumental vaginal delivery in nulliparous women after low concentration epidural infusions or opioid analgesia: systematic review. BMJ. 2004;328(7453):1410.

Wassen MM, Zuijlen J, Roumen FJ, Smits LJ, Marcus MA, Nijhuis JG. Early versus late epidural analgesia and risk of instrumental delivery in nulliparous women: a systematic review. BJOG. 2011;118(6):655-61.

Deepak D, Kumari A, Mohanty R, Prakash J, Kumar T, Priye S. Effects of epidural analgesia on labor pain and course of labor in primigravid parturients: a prospective non-randomized comparative study. Cureus. 2022;14(6):e26090.

Loftus JR, Hill H, Cohen SE. Placental transfer and neonatal effects of epidural sufentanil and fentanyl administered with bupivacaine during labor. Anesthesiology. 1995;83(2):300-8.

Wang Q, Zheng SX, Ni YF, Lu YY, Zhang B, Lian QQ, et al. The effect of labor epidural analgesia on maternal-fetal outcomes: a retrospective cohort study. Arch Gynecol Obstet. 2018;298(1):89-96.

Liu ZH, Wang DX. Potential impact of epidural labor analgesia on the outcomes of neonates and children. Chin Med J (Engl). 2020;133(19):2353-8.

D'Angelo R, Smiley RM, Riley ET, Segal S. Serious complications related to obstetric anesthesia: the serious complication repository project of the Society for Obstetric Anesthesia and Perinatology. Anesthesiology. 2014;120(6):1505-12.

Toledano RD, Leffert L. What's new in neuraxial labor analgesia. Curr Anesthesiol Rep. 2021;11(3):340-7.

Visalyaputra S. Maternal mortality related to anesthesia: Can it be prevented? Siriraj Med J. 2002;54(9):533-9.

Nivatpumin P, Lertbunnapong T, Bunfoo S. Obstetricians’ attitudes toward epidural analgesia for labor in a single university hospital in Thailand. Thai Journal of Obstetrics and Gynaecology. 2022;30(4):251-62.

Titapant V, Phithakwatchara N. Trends in modes of delivery in siriraj hospital. Siriraj Med J. 2007;59(6):271-3.

Smith A, Laflamme E, Komanecky C. Pain management in labor. Am Fam Physician. 2021;103(6):355-64.

Published

01-08-2024

How to Cite

Lertkovit, S., & Camann, W. R. . (2024). Effective Epidural Analgesia during Labor: A Feasible Method to Decrease Unnecessary Cesarean Deliveries in Thailand. Siriraj Medical Journal, 76(8), 541–549. https://doi.org/10.33192/smj.v76i8.268247