Pediatric Cancer Epidemiology for 2021–2023 Based on the Cancer Registry of Indonesia’s National Referral Hospital:

Olga Rasiyanti Siregar; Bidasari Lubis; Peggy  Liberty

doi:10.33192/smj.v77i2.271534

Authors

Olga Rasiyanti Siregar Department of Pediatrics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Bidasari Lubis Department of Pediatrics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Peggy Liberty Medical Study Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia

DOI:

https://doi.org/10.33192/smj.v77i2.271534

Abstract

Objective: This study aimed to present epidemiological data on pediatric cancers based on the hospital-based cancer registry (HBCR) at Indonesia’s National Referral Hospital.

Material and Methods: This descriptive study analyzed data on pediatric cancers from the HBCR for 2021–2023. Demographical data, including age, gender, diagnosis, and admission year, were extracted from the HBCR data. Univariate data analysis was conducted.

Results: This study included 344 patients, consisting of 202 males and 142 females. Of those patients, 92 (26.7%) were admitted in 2021, 142 (41.3%) in 2022, and 110 (32%) in 2023. The highest cancer incidence was observed in patients aged 2–5 years (34.9%) and the lowest in those aged <2 years (11.9%). The three most common reported cancers were lymphoid leukemia (47.4%), myeloid leukemia (11.6%), and retinoblastoma (9.6%).

Conclusion: Males predominated over females due to the substantial prevalence of leukemia cases. Most pediatric cancers were observed in those aged 2–5 years. While the distributions of cancer varied by age and gender, leukemia remained the leading pediatric cancer.

References

Huang J, Chan SC, Ngai CH, Lok V, Zhang L, Lucero-Prisno DE, et al. Global incidence, mortality and temporal trends of cancer in children: A joinpoint regression analysis. Cancer Med. 2023;12(2):1903-11.

Force LM, Abdollahpour I, Advani SM, Agius D, Ahmadian E, Alahdab F, et al. The global burden of childhood and adolescent cancer in 2017: an analysis of the Global Burden of Disease Study 2017. Lancet Oncol. 2019;20(9):1211-25.

Health Research and Development Agency: Basic Health Research 2018. Jakarta, Indonesia, Ministry of Health Republic of Indonesia, 2018. Available from: https://repository.badankebijakan.kemkes.go.id/id/eprint/3514/1/Laporan%20Riskesdas%202018%20Nasional.pdf

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424.

Prasetya D, Layyinah A, Putri S, Rosita E, Nurjanah AI, Maftuchan A. Financial Consequences of Cancer Treatment in Indonesia: A Study Case in the Capital City of Jakarta. Jakarta: Perkumpulan PRAKARSA, 2023.

Gondhowiardjo S, Hartanto S, Wirawan S, Jayalie VF, Astiti IAP, Panigoro SS, et al. Treatment delay of cancer patients in Indonesia: a reflection from a national referral hospital. Med J Indones. 2021;30(2):129-37.

Songmuang J, Akatat P, Wattanagulanurak S, Rittayamai N, Sripalakit S. Comparison Study between Using Disposable and Non-Disposable Ventilator Circuits on Ventilator-Associated Pneumonia and Health Care Costs at a Respiratory Care Unit, Siriraj Hospital. Siriraj Med J. 2023;75(3):191-9.

Supriyadi E, Purwanto I, Armytasari I, Ritter J, Widjajanto PH, Veerman AJP. A province-wide childhood malignancy profiles in Indonesia (2010-2019): Yogyakarta Pediatric Cancer Registry. Paediatr Indones. 2023;63(4):226-7.

Williams LA, Richardson M, Marcotte EL, Poynter JN, Spector LG. Sex ratio among childhood cancers by single year of age. Pediatr Blood Cancer. 2019;66(6):e27620.

Marcotte EL, Schraw JM, Desrosiers TA, Nembhard WN, Langlois PH, Canfield MA, et al. Male Sex and the Risk of Childhood Cancer: The Mediating Effect of Birth Defects. JNCI Cancer Spectr. 2020;4(5):pkaa052.

O'Neill KA, Murphy MF, Bunch KJ, Puumala SE, Carozza SE, Chow EJ, et al. Infant birthweight and risk of childhood cancer: international population-based case control studies of 40 000 cases. Int J Epidemiol. 2015;44(1):153-68.

Dunford A, Weinstock DM, Savova V, Schumacher SE, Cleary JP, Yoda A, et al. Tumor-suppressor genes that escape from X-inactivation contribute to cancer sex bias. Nat Genet. 2017;49(1):10-16.

Klein SL, Flanagan KL. Sex differences in immune responses. Nat Rev Immunol. 2016;16:626-38.

Amini M, Sharma R, Jani C. Gender differences in leukemia outcomes based on health care expenditures using estimates from the GLOBOCAN 2020. Arch Public Health. 2023;81(1):151.

Siegel DA, Li J, Henley SJ, Wilson RJ, Lunsford NB, Tai E, et al. Geographic Variation in Pediatric Cancer Incidence - United States, 2003-2014. MMWR Morb Mortal Wkly Rep. 2018;67(25):707-13.

Siegel DA, King JB, Lupo PJ, Durbin EB, Tai E, Mills K, et al. Counts, incidence rates, and trends of pediatric cancer in the United States, 2003-2019. J Natl Cancer Inst. 2023;115(11):1337-54.

Miranda-Filho A, Piñeros M, Ferlay J, Soerjomataram I, Monnereau A, Bray F. Epidemiological patterns of leukaemia in 184 countries: a population-based study. Lancet Haematol. 2018;5(1):e14-e24.

Chen J, Mullen CA. Patterns of Diagnosis and Misdiagnosis in Pediatric Cancer and Relationship to Survival. J Pediatr Hematol Oncol. 2017;39(3):e110-e15.

Gupta H, Malaichamy S, Mallipatna A, Murugan S, Jeyabalan N, Babu VS, et al. Retinoblastoma genetics screening and clinical management. BMC Med Genomics. 2021;14:188.

Mullen CJR, Barr RD, Franco EL. Timeliness of diagnosis and treatment: the challenge of childhood cancers. Br J Cancer. 2021;125(12):1612-20.

Arun ARK, Kumari BA, Ramachandra C, Vijay C R, Ramesh C, Apajji L, et al. National childhood cancer comprehensive management policy-a road map. Onkol Radioter. 2020;14(1):6-10.

Downing JR, Ghebreyesus TA. WHO Global Initiative for Childhood Cancer on the path to bridging the Survival Gap and attaining Universal Health Coverage: a 5-Year Review. WHO 2021.

Yang L, Yuan Y, Sun T, Li H, Wang N. Characteristics and trends in incidence of childhood cancer in Beijing, China, 2000-2009. Chin J Cancer Res. 2014;26(3):285-92.

Baade PD, Youlden DR, Valery PC, Hassall T, Ward L, Green AC, et al. Trends in incidence of childhood cancer in Australia, 1983-2006. Br J Cancer. 2010;102(3):620-6.

World Health Organization. Cancer Indones 2020 Country Profile. Available from: https://www.who.int/publications/m/item/cancer-idn-2020

Bhatnagar N, Qureshi A, Hall G. Leukaemias: a review. PCH. 2017;27(11):489-94.

Cui Y, Yan Y. The global burden of childhood and adolescent leukaemia and attributable risk factors: An analysis of the Global Burden of Disease Study 2019. J Glob Health. 2024;14:04045.

Stacey AW, Bowman R, Foster A, Kivelä TT, Munier FL, Cassoux N, et al. Incidence of Retinoblastoma Has Increased: Results from 40 European Countries. Ophthalmology. 2021;128(9):1369-71.

Global Retinoblastoma Study Group. The Global Retinoblastoma Outcome Study: a prospective, cluster-based analysis of 4064 patients from 149 countries. Lancet Glob Health. 202210(8):e1128-e40.

Ostrom QT, de Blank PM, Kruchko C, Petersen CM, Liao P, Finlay JL, et al. Alex's Lemonade Stand Foundation Infant and Childhood Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2007-2011. Neuro Oncol. 2015;16(Suppl 10):x1-x36.

Chang HY, Chiu CF, Jung SM, Wong AM, Wu CT, Lo FS. Neurological and endocrinological manifestations of 49 children with intracranial pure germinoma at initial diagnosis in Taiwan. Pediatr Neonatol. 2021;62(1):106-12.

Mbulaiteye SM, Devesa SS. Burkitt Lymphoma Incidence in Five Continents. Hemato 2022;3(3):434-53.

Ostrom QT, Cioffi G, Waite K, Kruchko C, Barnholtz-Sloan JS. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2014-2018. Neuro Oncol. 2021;23(12 Suppl 2):iii1-iii105.

Cunha KC, Oliveira MC, Gomes AC, de Castro LP, Viana MB. Clinical course and prognostic factors of children with Burkitt's lymphoma in a developing country: the experience of a single centre in Brazil. Rev Bras Hematol Hemoter. 2012;34(5):361-6.

Ngamdamrongkiat P, Arromdee E, Vongwiwatana A, Owattanapanich W, Sukpanichnant S. Histopathological and Clinical Features of Methotrexate-Associated Lymphoproliferative Disorders and Post-Transplant Lymphoproliferative Disorders. Siriraj Med J. 2022;74(9):575-89.

Barbosa AC, de Magalhães-Barbosa MC, Moreira JPL, Colombini GNUI, Prata-Barbosa A. Incidence of retinoblastoma in children and adolescents in Brazil: A population-based study. Front Pediatr. 2022;10:1048792.

Hofmann, I. Pediatric myelodysplastic syndromes. J Hematopathol. 2015;8:127-41.

Skapek SX, Ferrari A, Gupta AA, Lupo PJ, Butler E, Shipley J, et al. Rhabdomyosarcoma. Nat Rev Dis Primers. 2019;5(1):1.

Tayfun KF, Akınel AN, Akbaş H, Sivrice Ç, Kintrup GT, Karagüzel G, et al. Multidisciplinary Management of Pediatric Hepatoblastoma: A 20-Year Single-Center Experience. Turk J Gastroenterol. 2022;33(12):1069-78.

Kahla JA, Siegel DA, Dai S, Lupo PJ, Foster JH, Scheurer ME, et al. Incidence and 5-year survival of children and adolescents with hepatoblastoma in the United States. Pediatr Blood Cancer. 2022;69(10):e29763.

Wang X, Feng J, Li Z, Zhang X, Chen J, Feng G. Characteristics and prognosis of embryonal rhabdomyosarcoma in children and adolescents: An analysis of 464 cases from the SEER database. Pediatr Investig. 2020;4(4):242-9.

Balmant NV, De Souza Reis R, De Oliveira Santos M, Maschietto M, Camargo B. Incidence and mortality of bone cancer among children, adolescents and young adults of Brazil. Clinics. 2019;74:e858.

Riza M, Salimo H, Wasita B, Idulhaq M, Saputra RD, Widyaningsih V, et al. Survival and prognostic factors in pediatric osteosarcoma: A 5-year single-center experience in Central Java, Indonesia. Paediatr Indones. 2024;64(1):10.

Doganis D, Panagopoulou P, Tragiannidis A, Georgakis MK, Moschovi M, Polychronopoulou S, et al. Childhood nephroblastoma in Southern and Eastern Europe and the US: Incidence variations and temporal trends by human development index. Cancer Epidemiol. 2018;54:75-81.

Farouk FS, Viqar OA, Sheikh Z, Castro G, Barengo NC. The Association between Race and Survival among Pediatric Patients with Neuroblastoma in the US between 1973 and 2015. Int J Env Res Public Health. 2020;17(14):5119.