Platelet Rich Plasma as a Potential Treatment for Melasma: A Review
DOI:
https://doi.org/10.33192/smj.v77i3.271926Keywords:
Melasma, melasma treatment, platelet-rich plasma (PRP)Abstract
Melasma impacts millions of individuals globally. It is characterized by hyperpigmented macules that predominantly affect the centrofacial region. Although not medically dangerous, melasma can significantly diminish quality of life and overall well-being. Current therapeutic approaches offer varying degrees of efficacy, tolerance, and outcomes, underscoring the need for further research to identify treatments that are both effective and safe. Platelet-rich plasma (PRP), an autologous plasma enriched with a high concentration of platelets, has gained attention in the medical field for its regenerative properties and favorable benefit-risk profile. In dermatology and aesthetic medicine, PRP has demonstrated efficacy in applications such as wound healing, skin rejuvenation, alopecia, acne scarring, and, more recently, pigmentation disorders. This review explores the potential of PRP as a treatment modality for melasma, suggesting that PRP, whether used as an adjunctive or standalone therapy, may significantly enhance treatment outcomes. Nevertheless, despite promising evidence supporting its use, further research is required to establish robust biomolecular mechanisms and evaluate the long-term safety and efficacy of PRP in managing melasma.
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