Long-Term Refractive Outcomes Following Pediatric Cataract Surgery with Primary IOL Implantation
DOI:
https://doi.org/10.33192/smj.v78i5.280456Keywords:
Cataract, Pediatric ophthalmology, Myopic shiftAbstract
Objective: To evaluate long-term refractive outcomes following pediatric cataract surgery with primary intraocular lens (IOL) implantation.
Materials and Methods: A retrospective review was conducted on children younger than 13 years who underwent cataract surgery with primary IOL implantation at Siriraj Hospital between 2000 and 2020, with a minimum follow-up of 5 years. Refractive data were converted to spherical equivalents. Linear mixed models were used to analyze refractive shifts across four age groups (1 to <2.5, 2.5 to <4, 4 to <7, and 7 to <13 years) and identify influencing factors.
Results: The study included 71 eyes of 46 children, with a mean follow-up of 8.74 ± 3.01 years. The mean final refractive change ranged from -5.47 D (95% CI: -7.93, -3.01) in children aged 1 to <2.5 years to -1.33 D (95% CI: -1.99, -0.67) in those aged 7 to <13 years. Overall, only 30.99% of eyes achieved a final refraction within ±1.00 D of emmetropia. Multivariate analysis identified preoperative axial length (P = 0.005) and follow-up duration (P = 0.003) as significant predictors of refractive change.
Conclusion: Younger age at surgery correlates with greater magnitude and variability of myopic shift. Standard guidelines should be adapted to target higher residual hyperopia to achieve optimal long-term emmetropic refraction.
References
Rahi JS, Dezateux C, British Congenital Cataract Interest G. Measuring and interpreting the incidence of congenital ocular anomalies: lessons from a national study of congenital cataract in the UK. Invest Ophthalmol Vis Sci. 2001;42(7):1444–8.
Kim DG, Lee DY, Woo SJ, Park KH, Park SJ. Nationwide incidence of congenital and infantile cataract requiring surgery in Korea. Sci Rep. 2024;14(1):5251.
Weakley DR, Jr., Lynn MJ, Dubois L, Cotsonis G, Wilson ME, Buckley EG, et al. Myopic Shift 5 Years after Intraocular Lens Implantation in the Infant Aphakia Treatment Study. Ophthalmology. 2017;124(6):822–7.
Repka MX, Dean TW, Kraker RT, Li Z, Yen KG, de Alba Campomanes AG, et al. Visual Acuity and Ophthalmic Outcomes 5 Years After Cataract Surgery Among Children Younger Than 13 Years. JAMA Ophthalmol. 2022;140(3):269–76.
Enyedi LB, Peterseim MW, Freedman SF, Buckley EG. Refractive changes after pediatric intraocular lens implantation. Am J Ophthalmol. 1998;126(6):772–81.
Plager DA, Kipfer H, Sprunger DT, Sondhi N, Neely DE. Refractive change in pediatric pseudophakia: 6-year follow-up. J Cataract Refract Surg. 2002;28(5):810–5.
Crouch ER, Crouch ER, Jr., Pressman SH. Prospective analysis of pediatric pseudophakia: myopic shift and postoperative outcomes. J AAPOS. 2002;6(5):277–82.
Orazbekov L, Smagulova S, Ruslanuly K. Long-term Results of Congenital Cataract Surgery with Primary Intraocular Lens Implantation: A Case-Control Study of Three Age Groups. J Curr Ophthalmol. 2022;34(3):290–6.
VanderVeen DK, Oke I, Nihalani BR. Deviations From Age-Adjusted Normative Biometry Measures in Children Undergoing Cataract Surgery: Implications for Postoperative Target Refraction and IOL Power Selection. Am J Ophthalmol. 2022;239:190–201.
Pediatric Eye Disease Investigator G, de Alba Campomanes AG, Repka MX, Hatt SR, Sutherland DR, Leske DA, et al. Myopic Shift over 5 Years after Pediatric Lensectomy with Primary Intraocular Lens Implantation. Ophthalmology. 2025;132(3):290–8.
Lekskul A, Chuephanich P, Charoenkijkajorn C. Long-term outcomes of intended undercorrection intraocular lens implantation in pediatric cataract. Clin Ophthalmol. 2018;12:1905–11.
Wu PC, Huang HM, Yu HJ, Fang PC, Chen CT. Epidemiology of Myopia. Asia Pac J Ophthalmol (Phila). 2016;5(6):386–93.
Li Y, Jin G, Tan Y, Chen H, Jin J, Luo L, et al. Myopic shift after primary intraocular lens implantation in unilateral cataract children and its association with preoperative ocular parameters. J Cataract Refract Surg. 2025;51(1):53–9.
Troilo D, Wallman J. The regulation of eye growth and refractive state: an experimental study of emmetropization. Vision Res. 1991;31(7-8):1237–50.
Lambert SR, Archer SM, Wilson ME, Trivedi RH, del Monte MA, Lynn M. Long-term Outcomes of Undercorrection Versus Full Correction After Unilateral Intraocular Lens Implantation in Children. Am J Ophthalmol. 2012;153(4):602–8, 8 e1.
Valeina S, Heede S, Erts R, Sepetiene S, Skaistkalne E, Radecka L, et al. Factors influencing myopic shift in children after intraocular lens implantation. Eur J Ophthalmol. 2020;30(5):933–40.
Surachatkumtonekul T, Jaruniphakul P. Prevalence, Predictive Factors, and Surgical Outcomes of Strabismus in High Myopia. Siriraj Med J. 2026;78(3):175–84.
Trivedi RH, Barnwell E, Wolf B, Wilson ME. A Model to Predict Postoperative Axial Length in Children Undergoing Bilateral Cataract Surgery With Primary Intraocular Lens Implantation. Am J Ophthalmol. 2019;206:228–34.
Gouws P, Hussin HM, Markham RH. Long term results of primary posterior chamber intraocular lens implantation for congenital cataract in the first year of life. Br J Ophthalmol. 2006;90(8):975–8.
Hoevenaars NE, Polling JR, Wolfs RC. Prediction error and myopic shift after intraocular lens implantation in paediatric cataract patients. Br J Ophthalmol. 2011;95(8):1082–5.
Trivedi RH, Wilson ME, Jr. Changes in interocular axial length after pediatric cataract surgery. J AAPOS. 2007;11(3):225–9.
Infant Aphakia Treatment Study Group, Lambert SR, Lynn MJ, et al. Comparison of contact lens and intraocular lens correction of monocular aphakia during infancy: a randomized clinical trial of HOTV optotype acuity at age 4.5 years and clinical findings at age 5 years. JAMA Ophthalmol. 2014;132(6):676-82.
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