MRI Predictors of Survival in Patients with Glioblastomas

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Orasa Chawalparit

Abstract

Objective: To evaluate predictive value of MRI findings in overall survival of glioblastoma patients.
Methods:
A retrospective study was performed in 11 consecutive adult glioblastoma patients who underwent primary surgery, radiation and chemotherapy. The Kaplan-Meier curve was used to estimate overall survival probabilities. Fisher’s exact test or Mann-Whitney U Test was used to explore the association between clinical and imaging factors and 2-year survival.
Results:
The median survival for glioblastoma patients in this study was 963 days. Patients with tumor necrosis less than 50%, presence of pre-operative non-enhancing tumor (nCET), perilesional edema less than tumor volume, presence of cystic portion, absence of multifocality, extent of resection more than 50% involving noneloquent location, and the mass effect more than 5 mm had positive trends of longer survival (more than 2 years) implying better prognosis. However, no statistical significance was demonstrated.
Conclusion:
MR imaging features were useful predictors for survival in glioblastoma patients.

Keywords: MRI, glioblastoma, survival, predictor

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How to Cite
Chawalparit, O. (2015). MRI Predictors of Survival in Patients with Glioblastomas. Siriraj Medical Journal, 67(2). Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/55245
Section
Original Article

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