Performance Evaluation of the Coapresta®2000 Automated Coagulation analyzer for Screening Coagulogram

Authors

  • Chaicharoen Tantanate Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

Abstract

Objective: The Coapresta®2000 (CP) is an automated analyzer which can perform various coagulation assays. The author aimed to validate the CP performance for screening coagulogram testing, including APTT, PT, and fibrinogen assays, under our local situation such that the data could be applied to the laboratory in Thailand.
Methods: The real patients’ samples and control materials were used to evaluate the CP in terms of precision, reference range, comparability to the validated analyzer Sysmex® CS-2100i (CS), carryover, and turnaround time.
Results: The highest percentages of coefficient of variation of APTT, PT, and fibrinogen were 1.05, 3.92 and 2.53 for within run and 2.15, 2.71 and 6.53 for between run precision studies. The correlation coefficient of PT and fibrinogen between CP and CS were 0.99, while it was 0.77 for APTT. Considering warfarin dose adjustment, 6% of patients might require dose adjustment when using CP instead of CS. Carryover was not observed. The turnaround time of first specimen was less than 6 minutes for APTT and 3 minutes for PT and fibrinogen.
Conclusion: The performance of CP for screening coagulogram in terms of precision and carryover was acceptable. The turnaround time was short. The comparability between CP and CS was excellent for PT and fibrinogen, but was fair for APTT. The participation of external quality assurance scheme is needed to assess the accuracy.

Keywords: Coapresta®2000, automated analyzer, performance evaluation, screening coagulogram

Downloads

Published

10-04-2015

How to Cite

Tantanate, C. (2015). Performance Evaluation of the Coapresta®2000 Automated Coagulation analyzer for Screening Coagulogram. Siriraj Medical Journal, 67(2). Retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/55247

Issue

Vol. 67 No. 2 (2015): March-April

Section

Original Article

License

Users are free to share, copy, and redistribute all articles published in the Siriraj Medical Journal (SMJ) in any medium or format as long as you follow the following terms:

  • Attribution — You must give appropriate credit, provide a link to the material, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the publisher endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.