Relationship between Ischemia Modified Albumin and Metabolic Syndrome

Abstract

The aim of the study was to evaluate the association between ischemia modified albumin, inflammation markers, and lipids in patients with metabolic syndrome. In this case-control study, serum ischemia modified albumin, uric acid, lipid profile, insulin, fasting and non-fasting glucose, HbA1c, fibrinogen and CRP were measured in 47 patients with metabolic syndrome and 31 controls. International Diabetes Federation criteria were used for metabolic syndrome diagnosis. Ischemia modified albumin, uric acid, fibrinogen, total cholesterol, LDL, triglycerides and HOMA-IR were higher and HDL was lower in the patient group adjusted for body mass index and age. Significant correlations were observed between IMA and total cholesterol, triglycerides, HDL and LDL, fasting glucose, postprandial glucose, HOMA-IR, HbA1c, fibrinogen and CRP. We observed significant correlations also between CRP and fasting glucose, postprandial glucose, HOMA-IR, HbA1c, total cholesterol, triglycerides, HDL, LDL, uric acid and fibrinogen. Uric acid was also found as positively correlated with triglyceride, fasting glucose, HbA1c, HOMA-IR and negatively correlated with HDL. In conclusion, this case-control study has shown that higher levels of IMA and uric acid are strongly related to components of the metabolic syndrome. Both IMA and uric acid are independent risk factors for cardiovascular disease, so these easily measured parameters may add prognostic information to risk prediction. New investigations need to be done.

Keywords: C-reactive protein, fibrinogen, ischemia modified albumin, metabolic syndrome, uric acid