Predictors of Multiple Organ Dysfunction Syndrome in Patients with Major Trauma

Abstract

Objective: To study the predictive power of systemic inflammatory response syndrome (SIRS) scores, platelet count, and blood glucose level for multiple organ dysfunction syndrome (MODS) in patients with major trauma.
Methods: The sample was 87 patients with major trauma, hospitalized within 24 hours after injury. SIRS score, platelet count and maximum blood glucose level were measured within the first 24 hours after injury, while MODS was measured by the Denver post-injury multiple organ failure (MOF) score at the 3rd day after injury. Multiple regression analysis, using the enter method, was employed to analyze the data with a significance level of .05.
Results: The majority of the samples were male (85.1%) with an average age of 40.39 years. Most of them sustained multiple organ injuries and received surgical treatment within the first 24 hours. It was found that 25.3% of these patients developed organ dysfunction on the 3rd day after injury while 9.2% experienced MODS. SIRS score, platelet count and blood glucose level could predict MODS in patients with major trauma, with 41.7% of the variance explained (R2 = .417, p < .001).
Conclusion: Patients with major trauma should receive close monitoring on their SIRS score, platelet count and blood glucose level within 24 hours after injury. Moreover, Denver post-injury MOF score should be routinely used for detection of organ dysfunction so that preventative measures can be appropriately implemented.