Main Article Content
Objective: To establish a reference of normal fetal lung volume using three-dimentional ultrasonography in the second half of pregnancy.
Methods: A prospective longitudinal study was conducted in 53 Thai healthy singleton pregnant women at 22-37 weeks of gestation. By using 3-D ultrasonography with Virtual Organ Computer-Aided Analysis (VOCAL), the whole fetal thorax was obtained as volume data and then calculated in each participant for 3-6 successions. Our method showed excellent intraclass correlation coefficients (ICC = 0.990-0.991) among three operators and validity ranged within 3% of the actual volume. Multivariate analysis was used to identify the relationship between lung volume and gestational age. This longitudinal data set was then analysed by mixed model regression analysis.
Results: A total of 260 fetal lung volumes were obtained. Average maternal age, gestational age and birth weight were 26.9 ± 4.7 years, 38.9 ± 1.3 weeks and 3,007.5 ± 349.3 grams. With mixed model of regression analysis, the relationship between lung volume and GA was demonstrated as follows: left lung volume (ml.) = (-12.19) + (0.22*GA) + (0.03*GA2), right lung volume (ml.) = (-24.91) + (1.19*GA) + (0.02*GA2), total lung volume (ml.) = (-37.32) + (1.43*GA) + (0.05*GA2).
Conclusion: This is the normal fetal lung volume in the Thai population using the rotational technique (VOCAL). It could be considered as a reference for prenatal diagnosis of pulmonary hypoplasia.
All articles published in the Siriraj Medical Journal (SMJ) are protected by copyright. No material in this journal may be reproduced on any platform including electronic or in print or transmitted by any means, in whole or in part, without the prior written permission of the Editor of the SMJ. Written permission must also be obtained before any part of the SMJ is stored in any retrieval system of any nature.