Expression of Y2R mRNA Expression in Subcutaneous and Visceral Adipose Tissues Compared between Normal Weight and Obese Female Subjects
Keywords:
Y2R, PYY, NPY, obesityAbstract
Y2R mRNA expression in subcutaneous and visceral fat tissues as well as serum PYY levels between obese and normal weight subjects. We demonstrated that Y2R mRNA in visceral fat was greater (p<0.05) in normal weight subjects than in obese subjects with comparable expression in subcutaneous adipose tissue. Y2R mRNA was (p<0.05) expressed higher in subcutaneous than visceral fat tissue in obese subjects. Moreover, Y2R mRNA expression in subcutaneous fat tissue was positively correlated to its expression in visceral adipose tissues (R=0.932, p<0.001). In visceral fat, Y2R expression was negatively correlated with serum NPY levels (R=-0.415, p<0.05). Serum PYY was similar between obese and normal weight groups. In conclusion, higher Y2R mRNA expression in visceral fat tissue might be involved in lower adiposity. Further investigation regarding activation of Y2R action in visceral adipose tissue may reveal novel strategies for adiposity reduction.
Downloads
Published
How to Cite
Issue
Section
License
Users are free to share, copy, and redistribute all articles published in the Siriraj Medical Journal (SMJ) in any medium or format as long as you follow the following terms:
- Attribution — You must give appropriate credit, provide a link to the material, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the publisher endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes.
- NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.