Sensitivity and specificity of serum prostate - Specific antigen compared to histopathology in prostate cancer detection in Udonthani Hospital
Keywords:
Prostate cancer, Serum prostate Specific antigen, sensitivity, specificity, Udonthani hospitalAbstract
Background : Prostate cancer is the common cancer in male. Serum prostate - Specific antigen is a common tumor marker used widely to screen this cancer. There are many studies to evaluate PSA to detect prostate cancer but there is no study in Udonthani Hospital. This study aims to study sensitivity and specificity of serum prostate - Specific antigen compared to histopathology in prostate cancer detection.
Material and method : This study is an analytic study by retrospective data collection in 98 patients who performed serum PSA and tissue biopsy of prostate in Udonthani hospital between January to October 2021. The Sensitivity, Specificity, Positive predictive value, Negative predictive value , Area under the curve of ROC are calculated.
Result : Mean age is 70.67 +/- 7.48 (range 50-84 years old) Meann PSA is 100.90 +/- 417.05 ng/mL (range 0.0080-3770 ng/mL). Digital rectal examination (DRE) and tissue biopsy are performed in all patients. There are 38 adenocarcinoma. Gleason score ranges from 6 to 10 (mean 7.94 +/- 1.04) and Gleason score more than 8 are 20 patients. The combination of DRE and PSA show sensitivity range from 97.37% to 100%, specificity ranges from 31.67% to 80.00% , PPV ranges from 1.46 to 4.87, NPV ranges from 0.00 to 0.03, positive likelihood ratio ranges from 48.10% to 76.00%, negative likelihood ratio ranges from 97.96% to 100.00% and accuracy ranges 58.16% to 87.76%.
Discussion and conclusion : The combination of DRE and PSA show very high sensitivity and a high rate of prostate cancer detection rate. It is better than the PSA alone.That indicates the combination of physical examination and laboratory examination should be performed in all patients to detect prostate cancer.
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