Sensitivity and specificity of fine needle aspiration cytology in thyroid nodules in one tertiary center of Thailand
Keywords:
Thyroid nodule, Fine Needle Aspiration, Cytopathology, Khon Kaen HospitalAbstract
Objective : To study sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of FNA in thyroid nodules compared to histopathology.
Methods : We retrospective study with medical record review of 123 thyroid nodules with FNA and follow by surgery in Khon Kean hospital.
Result : Almost are women (88.6%). Average age is 48.7 years. The sensitivity 36.36% , Specificity 89.11%, Positive likelihood ratio 3.34, Negative likelihood ratio 0.71, Positive predictive value 42.11%, Negative predictive value 86.54%, Accuracy 79.67%
Conclusion : The low sensitivity is due to the high false negative rate in this study. The high specificity and high accuracy are satisfied. The false negative due to the papillary microcarcinoma and cystic papillary carcinoma. That report are benign follicular nodule in FNA. The false positive in conditions that found nuclear features characteristic of papillary carcinoma in benign thyroid lesions.
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