Causes of iron deficiency anemia in OPD Rajavithi hospital by esophagogastroduodenoscopy (EGD) and/or colonoscopy

Authors

  • ธนกฤต โปรยกลาง
  • กิตติ ชื่นยง

Abstract

Background : Majority of iron deficiency anemia (IDA) originate from gastrointestinal tract (GI) pathology. Regarding worldwide patients with IDA have to do GI endoscopic exam, at least esophagogastroduodenoscopy (EGD) and colonoscopy. Only 30 - 50% of IDA patients do not be endoscopic examed. Our study aims to evaluates causes of IDA using datas from EGD and colonoscopy from digestive endoscopy unit, department of internal medicine, Rajavithi Hospital. Objective : Study cause of IDA at digestive endoscopy unit, department of internal medicine, Rajavithi Hospital, The prevalence and causes were analyzed. In addition, the association between age, hemoglobin level and presence of fecal occult blood test (FOBT) to GI pathology and GI malignancy were also studied. Method : Datas from 164 patients with iron deficiency anemia those had been undergone EGD and/or colonoscopy from January 1st, 2013 to December, 31th 2015.

Results : From our study, abnormal GI endoscopic findings were found up to 67.7% of IDA patients. Three most common pathology including hemorrhagic/erosive gastritis or duodenitis (35.4%), gastric/duodenal ulcer (15.2%) and colorectal cancer (10.4%). No association between age, hemoglobin level and presence of FOBT to GI pathology and GI malignancy could be detected.

Conclusion : Our study showed that majority of IDA patients had GI pathology. Our result showed that no factors from age, hemoglobin level and presence of FOBT can predict the presence of GI pathology and GI malignancy, so that, patients with IDA should undergo GI endoscopy once diagnosed.

Keyword : iron deficiency anemia, esophagogastroduodenoscopy (EGD), colonoscopy

References

Zhu A, Kaneshiro M, Kaunitz JD, Evaluation and treatment of iron deficiency anemia : A Gastroenterological Perspective. Dig Dis Sci 2010;55:548-59.

Powell N, McNair A. Gastrointestinal evaluation of anemic patients without evidence of iron deficiency. Eur J Gastroenterolhepatol 2008;20:1094-100.

Zuckerman GR, Prakash C, Askin MP, Lewis BS. AGA technical review on the evaluation and management of occult and obscure gastrointestinal bleeding. Gastroenterology 2000;118:201-21.

Goddard AF, James MW , McIntyre AS, Scott BB. Guideline for management of iron deficiency anemia. Gut 2011;60:1309-16.

Rasul l, Kandel GP, An approach to iron deficiency anemia. Can J Gastroenterol 2001;15:739-47.

Stray N, Weberg R. A prospective study of same day bi-directional endoscopy in the evaluation of patients with occult gastrointestinal bleeding. Scand J Gastroenterol 2006;41:844-50.

Serefghanoglu S, Buyukasik Y, Emmungil H, et al. Identification of clinical and simple laboratory variables predicting responsible gastrointestinal lesions in patients with iron deficiency anemia. Int J Med Sci 2011;8:31-8.

Pongprasobchai S ,Sriprayoon T, Manatsanit S. Prospective evaluation of gastrointestinal lesions by bidirectional endoscopy in patients with iron deficiency anemia. J Med Assoc Thai 2011;94(11):1321-6.

Sophonthanasiri Y, Pisespongsa P, Praisontarangkul O, et al. Evaluation for gastrointestinal tract lesions in patients with iron deficiency anemia. Thai J Gastroenterol 2006;7(3):126-31.

วรายุ ปรัชญกุล. Gastrointestinal investigation in iron deficiency anemia . Clinical practice in Gastroenterology. 3rdedition .กรุงเทพฯ: สำนักพิมพ์กรุงเทพเวชสาร. 2557

Lwanga S K, Lemeshow S. Sample Size determination in health studies: A practical manual. Geneva: W.H.O. 1991; p25-42.

Wian FH, Jr., Urban JE, KefferJH,Kroft SH. Discriminating between iron deficiency anemia and anemia of chronic disease using traditional indices of iron status VS transferrrin receptor concentration. American journal of clinical pathology 2001;115:112-8.

Liu K, Kaffles AJ. Iron deficiency anemia : a review of diagnosis, investigation and management. European journal of gastroenterology &hepatology 2012;24:109-16.

Thomas JS, Dennis MJ. Gastrointestinal bleeding. Sleisenger and Fordtran’s Gastrointestinal and Liver Disease. 9thedition. Saunders Elsevier 2010;19:285-322.

Raju GS, Gerson L, Das A, Lewis B . American gastroenterological association (AGA) institute technical review on obscure gastrointestinal bleeding. Gastroenterology 2007;133:1697-1717

Fireman Z, Kopelman Y. The role of video capsule endoscopy in the evaluation of iron deficiency anaemia. Dig Liver Dis. 2004;36:97-102

Guyatt GH, Oxman AD, Ali M, Willan A, Acllroy W, Patterson C. Laboratory diagnosis of iron-deficiency anemia: an overview. J Gen Intern Med 1992;7:145-153

ปิยะพันธ์ พฤกษพานิช. A 55-year old male with anemic symptoms . Problems based GI case discussion . กรุงเทพฯ: โรงพิมพ์แห่งจุฬาลงกรณ์มหาวิทยาลัย. 2558

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Published

2019-06-25

How to Cite

โปรยกลาง ธ., & ชื่นยง ก. (2019). Causes of iron deficiency anemia in OPD Rajavithi hospital by esophagogastroduodenoscopy (EGD) and/or colonoscopy. Mahasarakham Hospital Journal, 13(3), 22–33. retrieved from https://he02.tci-thaijo.org/index.php/MKHJ/article/view/197599