Effect of Gynostemma pentaphyllum extract in reduction of plasma glucose level in pre-diabetic person
Abstract
Background : Gynostemma pentaphyllum (GP) is a plant which has reportedly affected on blood sugar by decreased gluconeogenesis in liver, decreased glycolysis from liver and increased beta-oxidation and glucose uptake to muscle cells.
Objective : To assess the effect of plasma glucose level in pre-diabetic person.
Methods : Quasi-experimental study. Sixty pre-diabetic volunteers were enrolled and assigned to 2 groups; simple randomized sampling for 30 volunteers in the experimental group and the left 30 volunteers in control group. The experimental group received 500 mg/day of GP extract and behavioral modification whereas the control group received behavioral modification only. Fasting blood sugar and HbA1c levels were measured at 0 and 12 weeks after the intervention. Clinical data were collected by the format of personal, behavioral and health status of volunteers including the format of FBS and HbA1c blood level before and after intervention of the two groups. The statistics were determined by Paired t-test and Independent t-test.
Results : At 12th week, the mean FBS level in the experimental group significantly decreased from 111.07 mg/dL to 105.20 mg/dL (P=0.002) but increased from 112.43 to 118.03 mg/dL (P=0.005) in the control group. At 12th week after intervention, the mean HbA1c level in experimental groups were not significantly decreased from 5.88% to 5.87% (P=0.98) but increased to 5.94% from 5.92% (P=0.63) in control group. However, the mean HbA1c levels were not changed from the baseline in both groups.
Conclusion : GP extract decreased FBS in pre-diabetic volunteers but did not affect HbA1c level.
Keywords: Gynostemma pentaphyllum extract, reduction of plasma glucose, pre-diabetic person
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