Fentanyl 100 ug for reduction pain on LCT propofol injection

Abstract

          Introduction : Propofol is well known induction agent in anesthesia. Pain on propofolinjection is acommon  problem in adults and children. There are several methods have been performed to attenuate its pain and make patients comfortable.

         Objective : To assess the effect of 100 ug of intravenous fentanyl on pain and severity of pain  duringpropofol injection

         Method : Prospective randomized double blind control trial was conducted in 100 patients at age of 18 to 64 years old with venous cannulation  at  dorsum of hand by catheter no. 20,  ASA physical status 1 and 2 underwent elective surgery under general anesthesia  were randomly allocated to 2 equal groups. They received 100 ug(50 ug/ml) of fentanyl and placebo (2 ml of NSS) intravenously 180 seconds pretreatment before LCT propofol injection.  Pain scores were assessed and recorded.

         Result : There were no significant difference in baseline characteristics between two groups. The incidence pain on propofol injection in placebo group was 94% and 62% in fentanyl group, absolute risk reduction in fentanyl group of 32 percentage points (95% CI, 17.0 to 47.0; P<0.001).The lower incidence of severe pain was observed in fentanyl group 20% compared with 62% in placebo group(95% CI, 25 to 59; P<0.001). The number needed to treat to prevent pain was 4(95% CI, 2.1 to 5.9). There were no significant difference in mild and moderate pain, pain on pretreatment drug and adverse skin reaction.

         Conclusion :  Intravenous 100 ug of fentanyl 180 seconds pretreatment is effective in attenuating pain on Long Chain Triglyceride propofol injection