Efficacy of GPO-VIR treatment on HIV-infected and AIDS patients with different CD4 levels in Kamalasai Hospital

Abstract

          This  retrospective  research  was  conducted  to  determine  the  efficacy  of  the  three  drug antiretroviral  tablet  (GPO-VIR)  containing  nevirapine, stavudine,  and  lamivudine  in  the  treatment  of  HIV-infected  and  AIDS  patients  with  varying  CD4  levels. The  participants  were  46  HIV  and  AIDS  patients  and  older  who  received  GPO-VIR  for  more  than  two  years  at  Kamalasai  Hospital, Kalasin   Province, in  the  period  from  October  2002  to  September  2010. CD4  were  counted  and  opportunistic infection  observed  after  6  12  18  and  24  month of  treatment. The  results  revealed  HIV/AIDS patients with CD4 levels mean increased every group and every time. The group has started CD4 <100 cells/mm³  at  0.001  level of significance since month   6  12 and 18  but month 24 were  found  the mean  were increased but not diferrent significantly  and group  CD4 were started at level ≥ 100  cells/mm³  were  found  increase at  0.05 level of significance  only  month 6  but   12  18 and   24   were  found  mean of CD4  level  increase significantly  but  not  different  significantly  beside  during  received  GPO-VIR  antiretroviral  drug  were not found opportunistic infection  which  were diferrent before received  drug  at  level  0.05  level of significance. Concluded  that  the drug GPO-VIR was effective  in  increase CD4  level   during  initial to 24  month  and  decrease  opportunistic  infection  of  HIV-infected  and  AIDS  patients especially  with  CD4  levels not low more