The Role of Liquid Simethicone in Enhancing Upper Gastrointestinal Endoscopic Visibility in Borabue Hospital: A prospective randomized controlled trial
Keywords:
Esophagogastroduodenoscopy, Simethicone, Mucosal visibility scoreAbstract
Objective : To compare the effectiveness of liquid Simethicone versus placebo on mucosal visibility in patients undergoing esophagogastroduodenoscopy (EGD).
Method : The prospective randomized controlled trial of 49 patients underwent EGD consisting of Simethicone (n=25) and placebo (n=24). The mucosal visibility score (MVS) was compared.
Result : At the lower esophagus, most MVS of the Simethicone group was MVS1, while the placebo group was MVS3 and not statistically significant (p=0.091). However, most MVS of the upper stomach, antrum, 1st and 2nd part of the duodenum was MVS1 and statistically significant compared to the placebo group (p=0.004, p<0.001, p=0.003, and p<0.001, respectively)
Conclusion : Simethicone increased the effectiveness of mucosal visibility. It also decreased the amount of water for flushing.
References
Keeratichananont S, Sobhonslidsuk A, Kitiyakara T, Achalanan N, Soonthornpun S. The role of liquid simethicone in enhancing endoscopic visibility prior to esophagogastroduodenoscopy (EGD): A prospective, randomized, double-blinded, placebo-controlled trial. J Med Assoc Thai. 2010;93(8):892-897.
Manfredi G, Bertè R, Iiritano E, et al. Premedication with simethicone and N-acetylcysteine for improving mucosal visibility during upper gastrointestinal endoscopy in a Western population. Endosc Int Open. 2021;9(2):E190-E194. doi:10.1055/a-1315-0114
Krishnamurthy V, Joseph A, Venkataraman S, Kurian G. Simethicone and N-acetyl cysteine combination as premedication before esophagogastroduodenoscopy: Double-blind randomized controlled trial. Endosc Int Open. 2022;10(5):E585-E592. Published 2022 May 13. doi:10.1055/a-1782-2003
Zhang LY, Li WY, Ji M, et al. Efficacy and safety of using premedication with simethicone/Pronase during upper gastrointestinal endoscopy examination with sedation: A single center, prospective, single blinded, randomized controlled trial. Dig Endosc. 2018;30(1):57-64. doi:10.1111/den.12952
Ahsan M, Babaei L, Gholamrezaei A, Emami MH. Simethicone for the Preparation before Esophagogastroduodenoscopy. Diagn Ther Endosc. 2011;2011:484532. doi:10.1155/2011/484532
Dangprasert, S. 2020. The Effect of Using High Dose Simethicone on the Visibility of Upper Gastrointestinal Endoscopy. Health Science Clinical Research. 35, 2 (Dec. 2020), 33–44.
Chen, Xueqin & Dai, Ning & Deng, Yanyong & Sun, Xin & Zhang, Mingqing & Pan, Jie & Huang, Zhiming & Ye, Guoliang & Si, Jianmin & Wang, Lan & Chen, Shujie. (2020). Prevention of White Flocculate Precipitation with Simethicone During Upper Gastrointestinal Endoscopy: A Double‐Blinded, Multi‐Center, Randomized Study. 10.21203/rs.3.rs-77068/v1.
Wu L, Cao Y, Liao C, Huang J, Gao F. Systematic review and meta-analysis of randomized controlled trials of Simethicone for gastrointestinal endoscopic visibility. Scand J Gastroenterol. 2011;46(2):227-235. doi:10.3109/00365521.2010.525714
Ofstead CL, Wetzler HP, Johnson EA, Heymann OL, Maust TJ, Shaw MJ. Simethicone residue remains inside gastrointestinal endoscopes despite reprocessing. Am J Infect Control. 2016;44(11):1237-1240. doi:10.1016/j.ajic.2016.05.016
Li Y, Du F, Fu D. The effect of using simethicone with or without N-acetylcysteine before gastroscopy: A meta-analysis and systemic review. Saudi J Gastroenterol. 2019;25(4):218-228. doi:10.4103/sjg.SJG_538_18
Chang WK, Yeh MK, Hsu HC, Chen HW, Hu MK. Efficacy of simethicone and N-acetylcysteine as premedication in improving visibility during upper endoscopy. J Gastroenterol Hepatol. 2014;29(4):769-774. doi:10.1111/jgh.12487
Mahawongkajit P, Kanlerd A. A prospective randomized controlled trial comparing simethicone, N-acetylcysteine, sodium bicarbonate and peppermint for visualization in upper gastrointestinal endoscopy. Surg Endosc. 2021;35(1):303-308. doi:10.1007/s00464-020-07397-8
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