Parathyroid carcinoma: Two cases report in Khon Kaen Hospital

Abstract

Objective : Parathyroid carcinoma is the rare malignant disease of endocrine tumor. The incidence is less than 1% of all patients with primary hyperparathyroidism in Western countries. The aim of this report was to illustrate two cases of parathyroid carcinoma in Khon Kaen hospital with a comprehensive literature review

Methods : Two patients with a diagnosis of parathyroid carcinoma in Khon Kaen hospital were included for this review

Result : The first case was a 24-year-old woman who had a midline neck mass for 4 months. Her blood calcium as high as 18.7 mg/dL. On examination, she has a firm midline neck mass is about 4 cm in diameter and. The total thyroidectomy was performed. The pathological diagnosis was parathyroid carcinoma. After that, she was loss follow up The second case report was a 53 years old lady present to the hospital complaining fatigue and midline neck mass. The investigation revealed severe hypercalcemia and hyperparathyroidism. Surgical exploration revealed an enlarged left parathyroid mass, 2.5 cm. Histological findings and immunohistochemical report confirmed as parathyroid carcinoma

Conclusion : Parathyroid cancer is a rare condition. Key clinical features may include the presence of a neck mass along with

 abnormally high blood calcium levels, as observed in two patients at Khon Kaen Hospital. These findings could indicate the possibility of a parathyroid tumor. Pathological diagnosis plays a crucial role, especially when cancer cells are found invading adjacent tissues, which is a definitive indicator of parathyroid cancer. In cases where the clinical presentation is complex or difficult to interpret, the use of special staining techniques can enhance diagnostic accuracy.