The Study of Drug-Drug Interactions at pharmacy outpatient department of Borabue hospital

Abstract

The objectives of this study were to investigate the incidence of drug-drug interactions to evaluate the acceptance rate of physician consulted by pharmacist to address drug-drug interaction problems.

This study was a prospective descriptive research, conducting at pharmacy outpatient department,Borabue Hospital.The software program called “DRUG INTERACTION FACTS ON DISC FOR WINDOW–JANUARY 1999 EDITION” and Drug  Interaction Analysis and Management 2007 , Drug Interaction Fact 2008 were used for indentifying  drug-drug interactions found  from the prescriptions containing at least two prescribed medicines. Data were collected during the working hours at pharmacy outpatient between March and April 2014. It was found that the incidence of drug-drug interactions were 10.23% per prescription. (1,021 prescriptions out of  9,976 in totals) From this figure,the number of drug-drug interaction problems were 2,841 in total.The incidence of drug-drug interaction problems indentified of significant level 1 was 6.57% (185/2841) followed by 36.85% (1037/2841) of significant level 2 , 11.16% (314/2841)  , 13.36% (376/2841) and 32.05% (902/2841) at significant level 3,4,5 respectively.The  acceptance rate of physicians consulted by pharmacist to address drug-drug interaction problems (significant level 1) was 52.97% (98/185)

This study can be applied to improve drug safety in health promoting hospital in order to decrease adverse events particularly  drug-drug interactions. Finally,the most effectiveness      of development will enhance to patients in part of saety and benefit from drug prescription.