Development of medicinal herbs from the extract of Chili and Phlai in emulgel
Keywords:
emulgel, emulsifier, phlai and chili extractsAbstract
Objective : The objective of this study was to develop an emulgel drug formulation that combines chili and phlai, both of which are listed in the national list of essential medicines. Aimed at effectively treating pain by harnessing the properties of both herbs.
Method : An experimental study was conducted to develop three formulations using pharmaceutical technology. The study aimed to adjust the amounts of two types of emulsifier, namely Span® 80 and Tween® 80, in the emulsion formulation before it was further developed into an emulgel. These formulations were evaluated based on their physical and chemical properties, and the best formulations were selected. The physical characteristics of the formulations, including compatibility, separation, viscosity, and pH, were evaluated on days 1 and 7. The chemical characteristics were via thin-layer chromatography for identifying chemical components, and high performance liquid chromatograph for determining the capsicum content. Stability tests were also conducted using the freeze-thaw cycling technique for six cycles.
Results : The second and third formulations exhibited desirable physicochemical properties. There was no statistically significant difference (p > 0.05) in the physical characteristics of the formulations. Evaluation of viscosity and pH of the formulations on days 1 and 7 for chemical characteristics showed that the developed formulations met the standard pharmacopeia criteria for capsicum content analysis.
Conclusion : The development of emulgel containing chili and phlai extracts conforms to pharmacopeia standards in term of physicochemical properties. Nevertheless, further studies are required to determine the efficacy and safety of this formulation.
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