Phototesting in lupus erythematosus:a literature review

Authors

  • Ruamporn Ngammongrkolrat DIVISION OF DERMATOLOGY, DEPARTMENT OF MEDICINE, FACULTY OF MEDICINE, RAMATHIBODI HOSPITAL, MAHIDOL UNIVERSITY, BANGKOK, THAILAND
  • Natta Rajatanavin DIVISION OF DERMATOLOGY, DEPARTMENT OF MEDICINE, FACULTY OF MEDICINE, RAMATHIBODI HOSPITAL, MAHIDOL UNIVERSITY, BANGKOK, THAILAND

Keywords:

Photosensitivity, Lupus erythematosus, photo-testing, photo-provocation

Abstract

Photosensitivity is a criteria to make a diagnosis of Systemic lupus erythematosus (SLE) according to Systemic lupus international collaborating clinics (SLICC) in 2012 and also an important sign and symptom in various subtype of cutaneous lupus erythematosus (CLE). There has been long observed that lupus erythematosus skin lesions can be experimentally reproduced by UVA and UVB irradiation. Several photo testing and photo-provocation protocols were used as a tool to induce skin lesions and objectively evaluate photosensitivity in SLE and CLE patients. However, most of the lupus patients have normal minimal erythematous dose (MED) to UV irradiation and the reaction to UV light may change during the course of the disease.  We reviewed recently photo-testing protocols and these data suggested that photo-provocation is a useful tool to confirmed photosensitivity in SLE and CLE patients.

References

Ruland V, Haust M, Stilling RM, et al. Updated analysis of standardized photoprovocation in patients with cutaneous lupus erythematosus. Arthritis Care Res (Hoboken). 2013;65:767-76.

Schmidt E, Tony HP, Brocker EB, Kneitz C. Sun-induced life-threatening lupus nephritis. Ann N Y Acad Sci 2007;1108:35-40.

Yu C, Gershwin ME, Chang C. Diagnostic criteria for systemic lupus erythematosus: a critical review. J Autoimmun. 2014;48-49:10-3.

Kuhn A, Ruland V, Bonsmann G. Photosensitivity, phototesting, and photoprotection in cutaneous lupus erythematosus. Lupus. 2010;19:1036-46.

Wolska H, Blaszczyk M, Jablonska S. Phototests in patients with various forms of lupus erythematosus. Int J Dermatol. 1989;28:98-103.

Lehmann P, Holzle E, Kind P, Goerz G, Plewig G. Experimental reproduction of skin lesions in lupus erythematosus by UVA and UVB radiation. J Am Acad Dermatol. 1990;22:181-7.

Kuhn A, Sonntag M, Richter-Hintz D, Oslislo C, Megahed M, Ruzicka T, et al. Phototesting in lupus erythematosus: a 15-year experience. J Am Acad Dermatol. 2001;45:86-95.

Kuhn A, Beissert S. Photosensitivity in lupus erythematosus. Autoimmunity. 2005;38:519-29.

Walchner M, Messer G, Kind P. Phototesting and photoprotection in LE. Lupus. 1997;6:167-74.

Sutej PG, Gear AJ, Morrison RC, Tikly M, de Beer M, Dos Santos L, et al. Photosensitivity and anti-Ro (SS-A) antibodies in black patients with systemic lupus erythematosus (SLE). Br J Rheumatol. 1989;28:321-4.

Sanders CJ, Van Weelden H, Kazzaz GA, Sigurdsson V, Toonstra J, Bruijnzeel-Koomen CA. Photosensitivity in patients with lupus erythematosus: a clinical and photobiological study of 100 patients using a prolonged phototest protocol. Br J Dermatol 2003;149:131-7.

Kuhn A, Wozniacka A, Szepietowski JC, Glaser R, Lehmann P, Haust M, et al. Photoprovocation in cutaneous lupus erythematosus: a multicenter study evaluating a standardized protocol. J Invest Dermatol. 2011;131:1622-30.

Kuhn A, Gensch K, Haust M, Meuth AM, Boyer F, Dupuy P, et al. Photoprotective effects of a broad-spectrum sunscreen in ultraviolet-induced cutaneous lupus erythematosus: a randomized, vehicle-controlled, double-blind study. J Am Acad Dermatol 2011;64:37-48.

Wozniacka A, Lesiak A, McCauliffe DP, Sysa-Jedrzejowska A. Photoprotective properties of chloroquine phosphate. J Eur Acad Dermatol Venereol 2007;21:1133-4.

Downloads

Published

2015-07-01

How to Cite

Ngammongrkolrat, R., & Rajatanavin, N. (2015). Phototesting in lupus erythematosus:a literature review. Thai Journal of Dermatology, 31(3), 180–186. retrieved from https://he02.tci-thaijo.org/index.php/TJD/article/view/282622

Issue

Section

Review article