Nalbuphine: Pharmacology Revisited
Keywords:
nalbuphine, pharmacokinetics, pharmacodynamicsAbstract
Nalbuphine is a synthetic opioid analgesic with a unique profile as a mixed agonist- antagonist. It acts as an antagonist at the mu-opioid receptor and an agonist at the kappa-opioid receptor, providing effective analgesia for moderate to severe pain while minimizing common opioid-related side effects such as respiratory depression, nausea, and pruritus. Notably, nalbuphine has a lower potential for dependence and abuse compared to traditional mu-opioid agonists. Its pharmacological properties make it a valuable option in various clinical settings, including labor analgesia and the management of opioid-induced pruritus.
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