Anesthetic Management of Radical Nephrectomy with Inferior Vena Cava Tumor Thrombus: a Case Report
Keywords:
anesthesia, hemodynamic monitoring, inferior vena cava, radical nephrectomy, renal cell carcinoma, tumor thrombusAbstract
Renal cell carcinoma may extend into the venous system; a condition associated with increased surgical and anesthetic complexity. Tumor thrombus involving the renal vein or inferior vena cava (IVC) poses significant perioperative challenges, including major bleeding, abrupt changes in venous return, and potential tumor embolization. We report the case of a 56-year-old patient with a large renal tumor and tumor thrombus involving the renal vein and the inferior vena cava who underwent radical nephrectomy. Perioperative management included balanced general anesthesia combined with single-shot spinal analgesia, invasive hemodynamic monitoring, vasoactive support, and goal-directed transfusion therapy guided by laboratory parameters and clinical assessment. The procedure was completed without major complications, highlighting the importance of structured perioperative preparation in high-risk oncologic surgeries.
References
Gainsburg DM, Pamnani A, Malhotra V. Miller’s anesthesia. MIller’s Anesthesia. Elsevier. 2024;p1804-32.
Tsuji Y, Goto A, Hara I, et al. Renal cell carcinoma with extension of tumor thrombus into the vena cava: surgical strategy and prognosis. J Vasc Surg. 2001;33:789-96.
Blute ML, Leibovich BC, Lohse CM, Cheville JC, Zincke H. The Mayo Clinic experience with surgical management complications and outcome for patients with renal cell carcinoma and venous tumour thrombus. BJU Int. 2004;94:33-41.
Chen K, Wang J, Dai J, et al. Anesthetic management of radical nephrectomy in patients with renal cell carcinoma involving renal vein or inferior vena cava. Tumori. 2019;105:411-6.
Shander A, Hardy JF, Ozawa S, et al. A global definition of patient blood management. Anesth Analg. 2022;135:476-88.
Chen S, Lu L, Zheng X, et al. Case report: Anesthetic management for removal of tumor thrombus in the inferior vena cava and pulmonary artery in renal cell carcinoma. Front Oncol. 2024;14:1372625.
Rodgers A, Walker N, Schug S, et al. Reduction of postoperative mortality and morbidity with epidural or spinal anaesthesia: results from overview of randomised trials. BMJ. 2000;321:1493.
Armengol-García C, Blandin-Alvarez V, López-García C, Flores-Villalba E. Combined general and neuraxial anesthesia versus general anesthesia alone for laparoscopic cholecystectomy: a meta-analysis of pain control and hemodynamic stability. Updates Surg. 2025;May1. doi.org/10.1007/s13304-025-02217-x
Horlocker TT, Vandermeuelen E, Kopp SL, Gogarten W, Leffert LR, Benzon HT. Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (Fourth Edition). Reg Anesth Pain Med. 2018;43:263-309.
Abel EJ, Thompson RH, Margulis V, et al. Perioperative outcomes following surgical resection of renal cell carcinoma with inferior vena cava thrombus extending above the hepatic veins: a contemporary multicenter experience. Eur Urol. 2014;66:584-92.
Poelaert JI, Schüpfer G. Hemodynamic monitoring utilizing transesophageal echocardiography: the relationships among pressure, flow, and function. Chest. 2005;127:379-90.
Reeves ST, Finley AC, Skubas NJ, et al. Basic perioperative transesophageal echocardiography examination: a consensus statement of the American Society of Echocardiography and the Society of Cardiovascular Anesthesiologists. J Am Soc Echocardiogr. 2013;26:443-56.
Barbara DW, Broski SM, Leibovich BC, Mauermann WJ. Inferior vena cava tumour thrombus and renal cell carcinoma. Can J Anaesth. 2018;65:588-9.
Abdelhamid S, Abuamra KS, Nabil A, Ibrahim H, Bagheri F, Weidinger C. Anesthetic management of recurrent renal cell carcinoma with complete obstruction of inferior vena cava (IVC): a case report. Cureus. 2025;17:e87079.
Zhang G, Palacios R, Hasoon J, Robinson CL, Nguyen A. Anesthetic management of a patient with renal cell carcinoma-associated venous thrombosis and massive transfusion. Orthop Rev (Pavia). 2024;16:122538.
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