Historical Control Data from Repeated Dose 90-days Oral Toxicity Studies of Wistar Rats (Mlac:WR)
Keywords:
Wistar rat, Historical control data, Toxicity studiesAbstract
The control group data of any parameters such as age, sex, food/water consumptions, hematological, clinical biochemistry parameters and organs weights were useful for toxicity studies. The aim of this study was to collect data from 13-week of Wistar rats (Mlac: WR) which the strain widely used for toxicity study and efficacy research. The data of this research consist of hematological parameters and clinical biochemistry parameters including organ weights in 239 rats (119 males and 120 females) were collected base on 8 repeated dose 90-days oral toxicity studies and the result were shown as maximum and minimum values, means and standard deviations. Thus, these historical control group data would help to support for interpret the effects of test items in toxicity studies that used Wistar rats for further study.
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