Factors Associated with Survival of the Elderly Patients with Advanced Non-Small Cell Lung Cancer in Saraburi Hospital: A Retrospective Cohort Study of Survival Analysis between 2010 and 2014

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Pintumas Autkittanon


          We conducted a study to evaluate the factor that might associate with survival of the elderly patients diagnosed with advanced Non-Small Cell Lung Cancer disease. A retrospective cohort of 78 patients with age of more than 70 years in Saraburi Hospital were enrolled between July 2010 and December 2014. The median age of the patients was 76 years. It was found that the Eastern Co-operation Oncology Group (ECOG) performance status was the significant factor associated with survival of the elderly patients with Hazard ratio 5.16 (p-value < 0.05, 95% CI 2.82-9.45). One, two and five years of survival were 21.79%, 6.41% and 2.56%, respectively. There was significant difference of median survival time between the elderly patients with and without receiving chemotherapy (10.8 and 1.5 months, p < 0.05). The Grade III-IV adverse effects of the elderly patients receiving chemotherapy were 13% (pneumonia and febrile neutropenia) but no treatment related death was found in this study. In conclusion, the ECOG performance status is the good prognostic factor for the overall survival in the elderly patients diagnosed with advanced Non-Small Cell Lung Cancer. It is a good guide for physician to treat the elderly patients with chemotherapy properly.


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