The Development of Transdermal Patch From Centella asiatica (L.) Urban

Abstract

       Asiatic pennywort or Centella asiatica (L.) Urban is a Herbal medicine, which is used for medicines, cosmetics, food supplement and health products. The pharmacological activities of pennywort are for wound healing, keloid treatment and antimicrobial activity. Transdermal drug patch for pennywort developed to reduce frequency for product usage per day. This helps for the pharmacy administration. The developed transdermal delivery system, was comprised of backing layer and adhesive layer which loaded herbal extraction. Different polymers such as ethyl cellulose (EC), eudragit E 100, eudragit NE 30 D, hydroxypropyl methyl cellulose with various concentrations (1.0%, 2.0% and 3.0% w/v) for backing layer and adhesive layer were studied. In addition, two plasticizers triacetin and dibutyl Phathalate (DBP) were also studied for the transdermal delivery system. The result demonstrated that 2.0% EC and 30% triacetin was suitable for backing layer in transdermal patch because transdermal patch was clear, flexible durable for tensile tester and contained few porosity detected by Scanning Electron Microscope (SEM). The preparation adhesive layer from polymer 6.0% eudragit NE 30 D and 0.5% DBP is the most appropriate for the system. The cell diffusion study by Franz’s method using high performance liquid chromatograph (HPLC) demonstrated that both active ingredients in pennywort, madecassoside and asiaticoside are found at 41.2% and 94.7%, respectively. The results of this study are use for new transdermal device for bedsore’s patient.