The Positive Predictive Value and Number Needed to Colonoscope of Fecal Immuno-Chemical Test 50 versus 100 for Colorectal Screening in Nakhonpathom Hospital
Keywords:
cut-off fecal immunochemistry test, colorectal cancer screening, positive predictive value, number needed to colonoscopyAbstract
Objective : Comparing positive predictive value and number needed to colonoscope between FIT 50 and FIT 100 for colorectal screening in Nakhonpathom Hospital.
Methods : In this retrospective study , asymptomatic participants , 50-70 years old with average risk for colorectal cancer, attended screening programs in Nakhon Pathom Province with FIT 50 in 2016 and FIT 100 in 2017. Positive predictive value, number needed to colonoscope, positive rate, dropout rate were collected and compared by using chi-square test
Results : All participants in colorectal screening program with FIT 50 were 4,100 and FIT 100 were 6,896. Comparing between FIT 50 with FIT 100 , we found that FIT positive rates were 12.7% and 3.6% (p<.001) respectively. Dropout rates were 28.9% and 14.9% (p<.001) respectively. Incidence rates of colorectal polyp were 3.0% and 1.1% (p<.001) and incidence rates of colorectal cancer were 0.37% and 0.17% (p=.049) in general population respectively. PPV for polyp were 34.3% and 30.8% (p=.356), PPV for cancer were 4.3% and 5.7% (p=.283), and PPV for both polyp and cancer were 38.6% and 36.5% (p=.659). Numbers needed to colonoscope of FIT 50 and 100 for polyp were 3 and 4 respectively. Numbers needed to colonoscope for cancer were 24 and 18 and numbers needed to colonoscope for both polyp and cancer were equally (3).
Conclusion : FIT 100 ng/ml is an appropriate tool for colorectal screening in a country which is limited to personal and colonoscopy resources due to equal PPV and lowering number needed to colonoscope when compares with FIT 50 ng/ml.
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ลิขสิทธิ์บทความเป็นของผู้เขียนบทความ แต่หากผลงานของท่านได้รับการพิจารณาตีพิมพ์ลงวารสารแพทย์เขต 4-5 จะคงไว้ซึ่งสิทธิ์ในการตีพิมพ์ครั้งแรกด้วยเหตุที่บทความจะปรากฎในวารสารที่เข้าถึงได้ จึงอนุญาตให้นำบทความในวารสารไปใช้ประโยชน์ได้ในเชิงวิชาการโดยจำเป็นต้องมีการอ้างอิงถึงชื่อวารสารอย่างถูกต้อง แต่ไม่อนุญาตให้นำไปใช้ในเชิงพาณิชย์
