Efficacy of Combined Oxytocin-Misoprostol Versus Oxytocin Alone in Reducing Blood Loss After Vaginal Deliveries : a Randomized Controlled Trial
Keywords:
postpartum hemorrhage, misoprostolAbstract
Objective: The aim was to study the efficacy in reducing blood loss after normal vaginal deliveries and side effects of misoprostol.
Methods: This was a randomized controlled trial conducted at Nakhonpathom Hospital from January to June 2021 including 200 women who had normal vaginal deliveries. Participants were randomized into 2 groups, 100 each. The Study group received combined oxytocin and misoprostol rectal suppositories, while the control group received oxytocin alone.
Results: The study group receiving oxytocin and misoprostol had average blood loss of 218.65±118.92 milliliter, whereas the control group had average blood loss of 292.00±199.34 milliliter, which was revealed having statistically significant difference (p-value = .005). Hematocrit decreased by 1.50±2.21% in the study group and by 2.66±2.70% in the control group which showed to have a statistically significant difference (p-value = .015). The study group experienced some side effects of misoprostol, namely a slight cold but no shivering. However, the control group did not experience any side effects.
Conclusion: Misoprostol rectal suppositories when used with oxytocin are effective in reducing postpartum blood loss after normal vaginal deliveries compared to oxytocin alone and have only few side effects.
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ลิขสิทธิ์บทความเป็นของผู้เขียนบทความ แต่หากผลงานของท่านได้รับการพิจารณาตีพิมพ์ลงวารสารแพทย์เขต 4-5 จะคงไว้ซึ่งสิทธิ์ในการตีพิมพ์ครั้งแรกด้วยเหตุที่บทความจะปรากฎในวารสารที่เข้าถึงได้ จึงอนุญาตให้นำบทความในวารสารไปใช้ประโยชน์ได้ในเชิงวิชาการโดยจำเป็นต้องมีการอ้างอิงถึงชื่อวารสารอย่างถูกต้อง แต่ไม่อนุญาตให้นำไปใช้ในเชิงพาณิชย์
