Factors Associated with the Decline of Forced Expiratory Volume in One Second Among Patients with Chronic Obstructive Pulmonary Disease Ratchaburi Hospital

Authors

  • Roengsak Singkarnjanarod M.D., Ratchaburi Hospital

Keywords:

COPD, FEV1 decline, spirometer

Abstract

Objective: The purpose is study factors associated with the Decline of forced expiratory volume in one second (FEV1) in patients with chronic obstructive pulmonary disease (COPD) in Ratchaburi Hospital.

Methods: This was a retrospective study. The relevant data were collected from medical records of patients diagnosed with COPD in Ratchaburi Hospital from January 1, 2016 to June 30, 2020 to identify factors associated with decrease of FEV1 using multiple regression analysis.

Results:  Eighty-four patients were included, 84.5% were male the mean age was 66.7 years. The annual reduction of FEV1 was 115.8 ml. after multiple regression analysis, the degree of smoking in the past, current cigarette smoker and the severity of COPD were related to the more reduction of FEV1. Of all factors, current cigarette smoking was the most important.

Conclusion: The current cigarette smoking is the most important factor related to reduction of FEV1 in patients with COPD. So cessation of smoking is advised in all COPD patients.

References

1. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for diagnosis, management, and prevention of COPD [Internet]. 2020 [cited 2020 Oct 27]; Available from: https://goldcopd.org/wp content/uploads/2019/11/GOLD-2020-REPORT-ver1.0wms.pdf
2. Lopez AD, Mathers CD, Ezzati M, et al. Global Burden of Disease and Risk Factors. Washington (DC): The International Bank for Reconstruction and Development / The World Bank; 2006.
3. Maranetra KN, Chuaychoo B, Dejsomritrutai W, et al. The prevalence and incidence of COPD among urban older persons of Bangkok Metropolis. J Med Assoc Thai. 2002;85(11):1147-55.
4. กลุ่มรายงานมาตรฐาน คลังข้อมูลสุขภาพ Health Data Center กระทรวงสาธารณสุข. [cited 2021 Oct 27]. Available from: https://hdcservice.moph.go.th/hdc/main/index.php
5. Fletcher C, Peto R. The natural history of chronic airflow obstruction. BMJ 1977;1(6077):1645–8.
6. Vestbo J, Edwards LD, Scanlon PD, et al. Changes in Forced Expiratory Volume in 1 Second over Time in COPD. N Engl J Med 2011;365(13):1184–92.
7. Sun Y, Milne S, Jaw JE, et al. BMI is associated with FEV1 decline in chronic obstructive pulmonary disease: a meta-analysis of clinical trials. Respir Res 2019;20(1):236.
8. Chen S, Wang C, Li B, et al. Risk factors for FEV1 decline in mild COPD and high-risk populations. COPD 2017;12:435–42.
9. Makris D, Moschandreas J, Damianaki A, et al. Exacerbations and lung function decline in COPD: New insights in current and ex-smokers. Respiratory Medicine 2007;101(6):1305–12.
10. Whittaker HR, Jarvis D, Sheikh MR, et al. Inhaled corticosteroids and FEV1 decline in chronic obstructive pulmonary disease: a systematic review. Respir Res 2019;20(1):277.

Published

2021-12-27

How to Cite

1.
Singkarnjanarod R. Factors Associated with the Decline of Forced Expiratory Volume in One Second Among Patients with Chronic Obstructive Pulmonary Disease Ratchaburi Hospital. Reg 4-5 Med J [internet]. 2021 Dec. 27 [cited 2025 Dec. 31];40(4):549-57. available from: https://he02.tci-thaijo.org/index.php/reg45/article/view/255545