The Effectiveness of Intravenous Dexamethasone Prophylaxis before Thyroidectomy in Reducing Postoperative Pain, Nausea, and Vomiting: A Prospective Randomized Controlled Trial
Keywords:
dexamethasone, effectiveness, postoperative nausea and vomiting, postoperative painAbstract
Pain and postoperative nausea and vomiting are common complications after thyroidectomy.
Objective: The aim of this study was comparing the effectiveness of prophylactic administration of 8-milligram intravenous dexamethasone with placebo before thyroidectomy in reducing postoperative pain, nausea, and vomiting.
Methods: This study was randomized controlled trial including 100 patients, 50 patients were received dexamethasone and 50 patients were received placebo. Numerical rating scale for pain and nausea and vomiting score were assessed at recovery room admission, 1 hour and 8 hours after surgery and analyzed by Independent t test for pain score and Fisher’s exact test for nausea and vomiting score.
Results: In dexamethasone group, the mean pain score was significantly lower at recovery room admission, mean ± SD (3.45 ± 1.50 vs 3.77 ± 1.64, p = .04) and postoperative nausea and vomiting incidence was significantly lower at one hour after surgery (1% vs 9%, p = .04) compare to placebo group. No significant differences were noted in pain score and nausea and vomiting score at eight hours after surgery.
Conclusion: A prophylactic 8-milligram intravenous dexamethasone in patients undergoing thyroidectomy is effective in reducing the mean pain score at recovery room admission and postoperative nausea and vomiting at one hour after surgery.
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ลิขสิทธิ์บทความเป็นของผู้เขียนบทความ แต่หากผลงานของท่านได้รับการพิจารณาตีพิมพ์ลงวารสารแพทย์เขต 4-5 จะคงไว้ซึ่งสิทธิ์ในการตีพิมพ์ครั้งแรกด้วยเหตุที่บทความจะปรากฎในวารสารที่เข้าถึงได้ จึงอนุญาตให้นำบทความในวารสารไปใช้ประโยชน์ได้ในเชิงวิชาการโดยจำเป็นต้องมีการอ้างอิงถึงชื่อวารสารอย่างถูกต้อง แต่ไม่อนุญาตให้นำไปใช้ในเชิงพาณิชย์
