Clinical factors associated with metabolic syndrome in psoriasis patients at Mahasarakham hospital
Abstract
Objective : To study clinical factors associated with metabolic syndrome in psoriasis patients
Methods : This study was retrospective cross-sectional analytical study. All data was collected from medical records of psoriasis patients who attended the dermatology clinic at Mahasarakham hospital during August 1st, 2017 to August 31st, 2019. The statistical analysis included descriptive statistics and analytic statistics. The statistical significance was set at p<0.05.
Results : Of 134 patients with psoriasis, 44% were metabolic syndrome. Men with psoriasis have a significantly decrease metabolic syndrome than women (p=0.002) OR 0.325 (0.160, 0.663). Psoriasis duration between metabolic and non-metabolic syndrome group was significant difference (p=0.025). Psoriasis with systemic therapy significantly higher in metabolic syndrome than topical therapy alone (p=0.021) OR 2.320 (1.125, 4.786). Cardiovascular risk in psoriasis with metabolic syndrome by Framingham risk score and Thai CV risk score found moderate to high risk (≥10%) 23.73% and 32.20%, respectively.
Conclusions : This study revealed female with psoriasis, psoriasis duration and systemic therapy of psoriasis were clinical factors associated with metabolic syndrome in psoriasis patients. Therefore, screening metabolic syndrome and prevent cardiovascular risk in the future were important for psoriasis patients.
Keywords : Psoriasis, metabolic syndrome, cardiovascular risk
References
Neimann AL, Shin DB, Wang X, Margolis DJ, Troxel AB, Gelfand JM. Prevalence of cardiovascular risk factors in patients with psoriasis. Journal of the American Academy of Dermatology. 2006;55(5):829–835.
Griffiths CEM, Iaccarino L, Naldi L, Olivieri I, Pipitone N, Salvarani C, et al. Psoriasis and psoriatic arthritis: immunological aspects and therapeutic guidelines. Clinical and experimental rheumatology. 2006;24(1):S72.
Terui T, Ozawa M, Tagami H. Role of neutrophils in induction of acute inflammation in T-cell-mediated immune dermatosis, psoriasis: a neutrophil-associated inflammation-boosting loop. Experimental Dermatology: Review Article. 2000;9(1):1–10.
Lowes MA, Kikuchi T, Fuentes-Duculan J, Cardinale I, Zaba LC, Haider AS, et al. Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. Journal of Investigative Dermatology. 2008;128(5):1207–1211.
สถาบันโรคผิวหนัง. โรคสะเก็ดเงิน Psoriasis.(ออนไลน์). เข้าถึงได้จาก http://inderm.go.th/news/myfile/21505bd05be937dbd_Psoriasis.pdf, สืบค้นเมื่อ 1 มิถุนายน 2562.
Cohen AD, Sherf M, Vidavsky L, Vardy DA, Shapiro J, Meyerovitch J. Association between psoriasis and the metabolic syndrome. Dermatology. 2008;216(2):152–155.
Alberti K, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; American heart association; world heart federation; international atherosclerosis society; and international association for the study of obesity. Circulation. 2009;120(16):1640–1645.
D’Agostino RB, Grundy S, Sullivan LM, Wilson P. Validation of the Framingham coronary heart disease prediction scores: results of a multiple ethnic groups investigation. Jama. 2001;286(2):180–187.
Mehta NN, Yu Y, Pinnelas R, Krishnamoorthy P, Shin DB, Troxel AB, et al. Attributable risk estimate of severe psoriasis on major cardiovascular events. The American journal of medicine. 2011;124(8):775–e1.
Sritara P, Cheepudomwit S, Chapman N, Woodward M, Kositchaiwat C, Tunlayadechanont S, et al. Twelve-year changes in vascular risk factors and their associations with mortality in a cohort of 3499 Thais: the Electricity Generating Authority of Thailand Study. International journal of epidemiology. 2003;32(3):461–468.
คณะแพทยศาสตร์โรงพยาบาลรามาธิบดี มหาวิทยาลัยมหิดล ศูนย์หัวใจหลอดเลือดและเมแทบอลิซึม. Thai CV risk score. เข้าถึงได้จาก https://med.mahidol.ac.th/ cvmc/th/event/ thaiCVriskscore, สืบค้นเมื่อ 1 มิถุนายน 2562.
Gulliver W. Long-term prognosis in patients with psoriasis. British Journal of Dermatology. 2008;159:2–9.
Takahashi H, Iizuka H. Psoriasis and metabolic syndrome. The Journal of dermatology. 2012;39(3):212–218.
Hugh J, Van Voorhees AS, Nijhawan RI, Bagel J, Lebwohl M, Blauvelt A, et al. From the Medical Board of the National Psoriasis Foundation: The risk of cardiovascular disease in individuals with psoriasis and the potential impact of current therapies. Journal of the American Academy of Dermatology. 2014;70(1):168–177.
Herron MD, Hinckley M, Hoffman MS, Papenfuss J, Hansen CB, Callis KP, et al. Impact of obesity and smoking on psoriasis presentation and management. Archives of dermatology. 2005;141(12):1527–1534.
Shapiro J, Cohen AD, David M, Hodak E, Chodik G, Viner A, et al. The association between psoriasis, diabetes mellitus, and atherosclerosis in Israel: a case-control study. Journal of the American Academy of Dermatology. 2007;56(4):629–634.
Cohen AD, Gilutz H, Henkin Y, Zahger D, Shapiro J, Bonneh DY, et al. Psoriasis and the metabolic syndrome. Acta dermato-venereologica. 2007;87(6):506–509.
Cohen AD, Weitzman D, Dreiher J. Psoriasis and hypertension: a case-control study. Acta dermato-venereologica. 2010;90(1):23–26.
Choi WJ, Park EJ, Kwon IH, Kim KH, Kim KJ. Association between psoriasis and cardiovascular risk factors in Korean patients. Annals of dermatology. 2010;22(3):300–306.
Gu D, Reynolds K, Wu X, Chen J, Duan X, Reynolds RF, et al. Prevalence of the metabolic syndrome and overweight among adults in China. The Lancet. 2005;365(9468):1398–1405.
Kim HM, Kim DJ, Jung IH, Park C, Park J. Prevalence of the metabolic syndrome among Korean adults using the new International Diabetes Federation definition and the new abdominal obesity criteria for the Korean people. Diabetes research and clinical practice. 2007;77(1):99–106.
Aekplakorn W, Kessomboon P, Sangthong R, Chariyalertsak S, Putwatana P, Inthawong R, et al. Urban and rural variation in clustering of metabolic syndrome components in the Thai population: results from the fourth National Health Examination Survey 2009. BMC Public Health. 2011;11(1):854.
Gisondi P, Tessari G, Conti A, Piaserico S, Schianchi S, Peserico A, et al. Prevalence of metabolic syndrome in patients with psoriasis: a hospital-based case–control study. British Journal of Dermatology. 2007;157(1):68–73.
Kokpol C, Aekplakorn W, Rajatanavin N. Prevalence and characteristics of metabolic syndrome in South-East Asian psoriatic patients: A case–control study. The Journal of dermatology. 2014;41(10):898–902
Fernández-Armenteros JM, Gómez-Arbonés X, Buti-Soler M, Betriu-Bars A, Sanmartin-Novell V, Ortega-Bravo M, et al. Psoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study. Journal of the European Academy of Dermatology and Venereology. 2019;33(1):128–135.
Adışen E, Uzun S, Erduran F, Gürer MA. Prevalence of smoking, alcohol consumption and metabolic syndrome in patients with psoriasis. Anais brasileiros de dermatologia. 2018;93(2):205–211.
Chularojanamontri L, Wongpraparut C, Silpa-Archa N, Chaweekulrat P. Metabolic syndrome and psoriasis severity in South-East Asian patients: an investigation of potential association using current and chronological assessments. The Journal of dermatology. 2016;43(12):1424–1428.
Katz HI, Waalen J, Leach EE. Acitretin in psoriasis: an overview of adverse effects. Journal of the American Academy of Dermatology. 1999;41(3):S7–S12.
Mehta NN, Krishnamoorthy P, Yu Y, Khan O, Raper A, Van Voorhees A, et al. The impact of psoriasis on 10-year Framingham risk. Journal of the American Academy of Dermatology. 2012;67(4):796–798.
Fernández-Torres R, Pita-Fernández S, Fonseca E. Psoriasis and cardiovascular risk. Assessment by different cardiovascular risk scores. Journal of the European Academy of Dermatology and Venereology. 2013;27(12):1566–1570.
Khankham S, Chularojanamontri L, Wongpraparut C, Silpa-archa N, Janyong N, Vathesatogkit P. Coronary artery events in Thai patients with psoriasis using Framingham and Ramathibodi-Electricity Generating Authority of Thailand risk scores. Asian biomedicine. 2015 Aug 1;9:495–500.
Griffiths CEM, Iaccarino L, Naldi L, Olivieri I, Pipitone N, Salvarani C, et al. Psoriasis and psoriatic arthritis: immunological aspects and therapeutic guidelines. Clinical and experimental rheumatology. 2006;24(1):S72.
Terui T, Ozawa M, Tagami H. Role of neutrophils in induction of acute inflammation in T-cell-mediated immune dermatosis, psoriasis: a neutrophil-associated inflammation-boosting loop. Experimental Dermatology: Review Article. 2000;9(1):1–10.
Lowes MA, Kikuchi T, Fuentes-Duculan J, Cardinale I, Zaba LC, Haider AS, et al. Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. Journal of Investigative Dermatology. 2008;128(5):1207–1211.
สถาบันโรคผิวหนัง. โรคสะเก็ดเงิน Psoriasis.(ออนไลน์). เข้าถึงได้จาก http://inderm.go.th/news/myfile/21505bd05be937dbd_Psoriasis.pdf, สืบค้นเมื่อ 1 มิถุนายน 2562.
Cohen AD, Sherf M, Vidavsky L, Vardy DA, Shapiro J, Meyerovitch J. Association between psoriasis and the metabolic syndrome. Dermatology. 2008;216(2):152–155.
Alberti K, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; American heart association; world heart federation; international atherosclerosis society; and international association for the study of obesity. Circulation. 2009;120(16):1640–1645.
D’Agostino RB, Grundy S, Sullivan LM, Wilson P. Validation of the Framingham coronary heart disease prediction scores: results of a multiple ethnic groups investigation. Jama. 2001;286(2):180–187.
Mehta NN, Yu Y, Pinnelas R, Krishnamoorthy P, Shin DB, Troxel AB, et al. Attributable risk estimate of severe psoriasis on major cardiovascular events. The American journal of medicine. 2011;124(8):775–e1.
Sritara P, Cheepudomwit S, Chapman N, Woodward M, Kositchaiwat C, Tunlayadechanont S, et al. Twelve-year changes in vascular risk factors and their associations with mortality in a cohort of 3499 Thais: the Electricity Generating Authority of Thailand Study. International journal of epidemiology. 2003;32(3):461–468.
คณะแพทยศาสตร์โรงพยาบาลรามาธิบดี มหาวิทยาลัยมหิดล ศูนย์หัวใจหลอดเลือดและเมแทบอลิซึม. Thai CV risk score. เข้าถึงได้จาก https://med.mahidol.ac.th/ cvmc/th/event/ thaiCVriskscore, สืบค้นเมื่อ 1 มิถุนายน 2562.
Gulliver W. Long-term prognosis in patients with psoriasis. British Journal of Dermatology. 2008;159:2–9.
Takahashi H, Iizuka H. Psoriasis and metabolic syndrome. The Journal of dermatology. 2012;39(3):212–218.
Hugh J, Van Voorhees AS, Nijhawan RI, Bagel J, Lebwohl M, Blauvelt A, et al. From the Medical Board of the National Psoriasis Foundation: The risk of cardiovascular disease in individuals with psoriasis and the potential impact of current therapies. Journal of the American Academy of Dermatology. 2014;70(1):168–177.
Herron MD, Hinckley M, Hoffman MS, Papenfuss J, Hansen CB, Callis KP, et al. Impact of obesity and smoking on psoriasis presentation and management. Archives of dermatology. 2005;141(12):1527–1534.
Shapiro J, Cohen AD, David M, Hodak E, Chodik G, Viner A, et al. The association between psoriasis, diabetes mellitus, and atherosclerosis in Israel: a case-control study. Journal of the American Academy of Dermatology. 2007;56(4):629–634.
Cohen AD, Gilutz H, Henkin Y, Zahger D, Shapiro J, Bonneh DY, et al. Psoriasis and the metabolic syndrome. Acta dermato-venereologica. 2007;87(6):506–509.
Cohen AD, Weitzman D, Dreiher J. Psoriasis and hypertension: a case-control study. Acta dermato-venereologica. 2010;90(1):23–26.
Choi WJ, Park EJ, Kwon IH, Kim KH, Kim KJ. Association between psoriasis and cardiovascular risk factors in Korean patients. Annals of dermatology. 2010;22(3):300–306.
Gu D, Reynolds K, Wu X, Chen J, Duan X, Reynolds RF, et al. Prevalence of the metabolic syndrome and overweight among adults in China. The Lancet. 2005;365(9468):1398–1405.
Kim HM, Kim DJ, Jung IH, Park C, Park J. Prevalence of the metabolic syndrome among Korean adults using the new International Diabetes Federation definition and the new abdominal obesity criteria for the Korean people. Diabetes research and clinical practice. 2007;77(1):99–106.
Aekplakorn W, Kessomboon P, Sangthong R, Chariyalertsak S, Putwatana P, Inthawong R, et al. Urban and rural variation in clustering of metabolic syndrome components in the Thai population: results from the fourth National Health Examination Survey 2009. BMC Public Health. 2011;11(1):854.
Gisondi P, Tessari G, Conti A, Piaserico S, Schianchi S, Peserico A, et al. Prevalence of metabolic syndrome in patients with psoriasis: a hospital-based case–control study. British Journal of Dermatology. 2007;157(1):68–73.
Kokpol C, Aekplakorn W, Rajatanavin N. Prevalence and characteristics of metabolic syndrome in South-East Asian psoriatic patients: A case–control study. The Journal of dermatology. 2014;41(10):898–902
Fernández-Armenteros JM, Gómez-Arbonés X, Buti-Soler M, Betriu-Bars A, Sanmartin-Novell V, Ortega-Bravo M, et al. Psoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study. Journal of the European Academy of Dermatology and Venereology. 2019;33(1):128–135.
Adışen E, Uzun S, Erduran F, Gürer MA. Prevalence of smoking, alcohol consumption and metabolic syndrome in patients with psoriasis. Anais brasileiros de dermatologia. 2018;93(2):205–211.
Chularojanamontri L, Wongpraparut C, Silpa-Archa N, Chaweekulrat P. Metabolic syndrome and psoriasis severity in South-East Asian patients: an investigation of potential association using current and chronological assessments. The Journal of dermatology. 2016;43(12):1424–1428.
Katz HI, Waalen J, Leach EE. Acitretin in psoriasis: an overview of adverse effects. Journal of the American Academy of Dermatology. 1999;41(3):S7–S12.
Mehta NN, Krishnamoorthy P, Yu Y, Khan O, Raper A, Van Voorhees A, et al. The impact of psoriasis on 10-year Framingham risk. Journal of the American Academy of Dermatology. 2012;67(4):796–798.
Fernández-Torres R, Pita-Fernández S, Fonseca E. Psoriasis and cardiovascular risk. Assessment by different cardiovascular risk scores. Journal of the European Academy of Dermatology and Venereology. 2013;27(12):1566–1570.
Khankham S, Chularojanamontri L, Wongpraparut C, Silpa-archa N, Janyong N, Vathesatogkit P. Coronary artery events in Thai patients with psoriasis using Framingham and Ramathibodi-Electricity Generating Authority of Thailand risk scores. Asian biomedicine. 2015 Aug 1;9:495–500.
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2020-01-09
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กีรติมหาตม์ อ. (2020). Clinical factors associated with metabolic syndrome in psoriasis patients at Mahasarakham hospital. Mahasarakham Hospital Journal, 16(3), 203–214. retrieved from https://he02.tci-thaijo.org/index.php/MKHJ/article/view/234710
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