Quantity of restricted parenteral antimicrobial use and its relationship with antimicrobial susceptibility: case of super-tertiary hospital in Northeastern

Abstract

This retrospective study collected the data of 7 antimicrobial consumption and antimicrobial susceptibility report of 7 microorganisms from the electronic database of Srinagarind hospital during 2016-2018.  The amount of antimicrobial use was calculated as DDD/1000 patient-days. The trends of antimicrobial consumption and antimicrobial susceptibility were assessed using descriptive statistics. From 3 years of hospital data, the antimicrobials with highest consumption was meropenem, followed by piperacillin/tazobactam and vancomycin that were 69.86, 48.29 and 22.43 DDD/1000 patient-day each year, respectively. Piperacillin/tazobactam and ertapenem had increased consumption rate yearly meanwhile fosfomycin and cefoperazone/sulbactam had decreased consumption rate yearly. Most gram positive bacteria were susceptible to antimicrobials over 80% except for E.faecium susceptible to fosfomycin under 80%. Most gram negative bacteria were susceptible to antimicrobials under 80% except for E.coli susceptible to antimicrobials over 80%. Piperacillin/tazobactam consumption tended to increase as same as drug susceptibility of K.pneumoniae but contrast to drug susceptibility of P.aeruginosa. Ertapenem consumption tended to increase as same as drug susceptibility of A.baumannii, E.coli and K.pneumoniae. Fosfomycin consumption tended to decrease as same as drug susceptibility of K.pneumoniae but contrast to drug susceptibility of A.baumannii. In conclusion, antimicrobial consumptions and antimicrobial susceptibility presented similar fashion only in some agents.