Prevalence and Factors Associated with Renal Dysfunctionin Patients on Tenofovir Disoproxil Fumarate-BasedAntiretroviral Regimens for HIV Infection in a Community Hospital

Abstract

This study was a retrospective cohort study, reviewing the medical records of HIV-infected patients who took TDF-containing antiretroviral therapy (ART) regimens at a community hospital between 2015 and 2019. Assessments of renal dysfunction were made observing the rapid decline of estimated glomerular filtration rates (eGFR) or creatinine clearance (CrCl) greater than 3 mL/min/1.73 m² from the baseline and proximal tubular dysfunction. Data analysis was performed through descriptive and multivariate logistic regression. The results showed that 167 patients were included in the study with average age of 46.05 years (SD 10.06). Renal dysfunction was determined by examining the rapid decline of eGFR and proximal tubular dysfunction prevalence at the 6^th, 12^th, 18^th, and 24^th months, and the dysfunction rates were 22.75%, 16.03%, 18.84%, and 14.56%, respectively. Age over 50 years old was a risk factor associated with renal dysfunction. Renal dysfunction was determined by observing a rapid decline of CrCl and proximal tubular dysfunction prevalence at the 6^th, 12^th, 18^th, and 24^th months, were 8.98%, 18.59%, 16.55%, and 13.59 %, respectively. Taking cotrimoxazole prophylaxis, body mass index under 18.5 kg/m², and female gender were risk factors.