Pregnancy Outcome and Congenital Syphilis in Maternal Syphilis Infection in Rayong Hospital between 2018 and 2020

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apiradee uthaipaisanwong


          Syphilis in pregnant women can transmit to the fetus via placental blood circulation and amniotic fluid. Maternal syphilis is associated with poor pregnancy and neonatal outcomes, such as fetal death, preterm birth and congenital syphilis. This retrospective descriptive study aimed to evaluate pregnancy and neonatal outcomes of maternal syphilis at Rayong Hospital, including the prevalence of maternal and congenital syphilis and associated risk factors. Medical records of pregnant women diagnosed with maternal syphilis and delivered at Rayong hospital from April 2018 to Mar 2020 were reviewed. A total of 99 pregnant women were studied with the mean age of about 21.5 years. Of 99 pregnant women, 26 newborns were diagnosed with symptomatic congenital syphilis, which 5 cases resulted in fetal death. The prevalence of maternal syphilis was 0.7% in 2018 and increased to 1.3% in 2019. Almost half (42.3%) of the newborns with congenital syphilis were preterm birth and 15.4% were small for gestational age. Absence of antenatal care, no syphilis treatment in the third trimesters, inadequate syphilis treatment, and no treatment in maternal syphilis were significantly associated with congenital syphilis (p<0.01). In conclusion, this study revealed that the prevalence of maternal syphilis increased over the years, followed by subsequently increased prevalence of congenital syphilis. Health policy to encourage antenatal care and complete treatment of maternal syphilis at least 30 days prior to the delivery can improve both pregnancy and neonatal outcomes.


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