Risk Assessment of Dietary Exposure to Cadmium in the Thai Population

Authors

  • Panawan Kluengklangdon Bureau of Quality and Safety of Food, Department of Medical Sciences
  • Laddawan Rojanapantip Bureau of Quality and Safety of Food, Department of Medical Sciences
  • Kannika Jittiyossara Bureau of Quality and Safety of Food, Department of Medical Sciences
  • Nontarat Pornsapmanee Regional Medical Sciences Center 12/1 Trang, Department of Medical Sciences
  • Pinnaree Chinwattanawong Regional Medical Sciences Center 1 Chiang Mai, Department of Medical Sciences
  • Khemikar Hemloha Regional Medical Sciences Center 11 Surat Thani, Department of Medical Sciences

Keywords:

risk assessment of cadmium, dietary exposure

Abstract

       Cadmium (Cd) is often found in almost foods and its contamination level depends on the type of food and the contamination in environment. Food consumption is the main source of cadmium intake for people who do not smoke or work in contaminated areas. The cadmium has been classified as a human carcinogen. In 2010, the Joint FAO/WHO Expert Committee on Food Additives (JECFA) established a provisional tolerable monthly intake (PTMI) on cadmium exposure of 25 μg/kg body weight/month. This research had been carried out during 2011 - 2013 and aimed at assessing the risk of cadmium exposure via food consumption among Thai population. The current results obtained can be served as a supportive data for establishing Thai regulations as well as supporting improvement of the international standards. In the step of exposure assessment of Cd by duplicate portion method, the food consumption data, sample of food and water were collected from 400 households in four regions of Thailand for a period of 4 days. The total number of 1,241 people, 1,600 samples of food and 400 samples of water were analyzed in this study. The Cd concentration was quantified by Graphite Furnace Atomic Absorption Spectrophotometer and Inductively Coupled Plasma Optical Emission Spectrometer. The results showed that the middle bound mean levels of cadmium found in food and water samples were 0.009 mg/kg and 7 × 10-4 mg/L respectively and the mean intakes of food and water were 1,506 g/person/day and 1,832 mL/person/day, respectively. The middle bound mean dietary exposure across Thai consumers was 7.29 μg/kg body weight/month (average body weight of 58 kg) which was equal to 29% of the PTMI value. In conclusion, Thai consumers are still safe from cadmium exposure through food consumption.

References

Jarup L. Hazards of heavy metal contamination. Br Med Bull 2003; 68: 167-82.

European Food Safety Authority. Cadmium dietary exposure in the European population. EFSA Journal [online]. 2012 [cited 2016 Nov 15]; 10(1): [37 pp]. Available from: URL: https://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2012.2551/epdf.

United Nations Environment Programme, Chemicals Branch, DTIE. Final review of scientific information on cadmium [online]. 2010 [cited 2016 Nov 15]. Available from: URL: https://drustage.unep.org/chemicalsandwaste/sites/unep.org.chemicalsandwaste/files/publications/GAELP_PUB_UNEP_GC26_INF_11_Add_2_Final_UNEP_Cadmium_review_and_apppendix_Dec_2010.pdf.

IPCS INCHEM. Environmental health criteria 134, cadmium. Geneva: World Health Organization; 1992. [cited 2016 Sep 1]. Available from: URL: https://www.inchem.org/documents/ehc/ehc/ehc134.htm.

European Food Safety Authority. Scientific opinion cadmium in food scientific opinion of the panel on contaminants in the food chain. The EFSA Journal [Internet]. 2009 [cited 2016 Sep 1]; 980: 1-139. Available from: URL: https://www.efsa.europa.eu/sites/default/files/scientific_output/files/main_documents/980.pdf.

Godt J, Scheidig F, Grosse-Siestrup C, Esche V, Brandenburg P, Reich A, et al. The toxicity of cadmium and resulting hazards for human health. J Occup Med Toxicol [online]. 2006 [cited 2016 August 11]; 1(22): [6 screens]. Available from: URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1578573/pdf/1745-6673-1-22.pdf.

Jarup L, Akesson A. Current status of cadmium as an environmental health problem. Toxicol Appl Pharmacol 2009; 238(3): 201-8.

World Health Organization, Food and Agriculture Organization of the United Nations. Joint FAO/WHO food standards programme, Discussion paper on cadmium (CX/FAC 99/21). The Hague, Netherlands; 22-26 March 1999.

U.S. Department of Health and Human Services. Toxicological profile for cadmium. Atlanta, Georgia: Agency for Toxic Substance and Disease Registry; 2012.

Norwegian Scienticfic Committee for Food Safety. Risk assessment of dietary cadmium exposure in the Norwegian population. [online]. 2015 [cited 2016 Sep 1]; [101 screens]. Available from: URL: https://www.vkm.no/dav/07cfa5d365.pdf

Olsson IM, Bensryd I, Lundh T, Ottosson H, Skerfving S, Oskarsson A. Cadmium in blood and urine-impact of sex, age, dietary intake, iron status, and former smoking-association of renal effects. Environ Health Perspect 2002; 110(12): 1185-90.

International Agency for Research on Cancer WHO. IARC Monographs on the evaluation of carcinogenic risk to humans. [online]. [cited 2016 Sep 1]. Available from: URL: https://monographs.iarc.fr/ENG/Classification/latest_classif.php

WHO. Evaluations of the joint FAO/WHO expert committee on food additives (JECFA), Cadmium. [online]. 2013 [cited 2016 Sep 1]; [1 screens]. Available from: URL: https://apps.who.int/food-additives-contaminants-jecfa-database/chemical.aspx?chemID=1376

มยุรี อุรารุ่งโรจน์, ประกาย บริบูรณ์, พนาวัลย์ กลึงกลางดอน. การศึกษาปริมาณโลหะเป็นพิษในอาหารที่คนไทยบริโภคต่อวัน ระหว่าง พ.ศ. 2542-2544. ว กรมวิทย พ 2548; 47(4): 234-47.

ประกาศกระทรวงสาธารณสุข ฉบับที่ 98 (พ.ศ. 2529) เรื่อง มาตรฐานอาหารที่มีสารปนเปื้อน. ราชกิจจานุเบกษา เล่มที่ 103 ตอนที่ 23 ง ฉบับพิเศษ (วันที่ 16 กุมภาพันธ์ 2529)

World Health Organization. Application of risk analysis to food standard issue. Report of the joint FAO/WHO expert consultation. Geneva, Switzerland. 13-17 March 1995 [online]. [cited 2016 Sep 1]; [45 screens]. Available from: URL: https://apps.who.int/iris/bitstream/10665/58913/1/WHO_FNU_FOS_95.3.pdf

World Health Organization. Guideline for the study of dietary intake of chemical contaminants. Geneva: World Health Organization; 1985.

AOAC International. AOAC official method 999.10 lead, cadmium, zinc, copper and iron in foods. In: Horwitz W, Latimer GW, editors. Official method of analysis of AOAC international. 18th ed. Maryland: AOAC International; 2011. Chapter 9 p.16-19.

American Public Health Association. Standard methods for the examination of water and wastewater. 22nd ed. Maryland: American Public Health Association; 2012.

สำนักมาตรฐานสินค้าเกษตรและอาหารแห่งชาติ. ข้อมูลการบริโภคอาหารของประเทศไทย. [ออนไลน์]. 2559 [สืบค้น 1 ก.พ. 2560]. เข้าถึงได้จาก : URL: https://www.acfs.go.th/document/download_document/FCDT.pdf

Liu P, Wang CN, Song XY, Wu YN. Dietary intake of lead and cadmium by children and adults-result calculated from dietary recall and available lead/cadmium level in food in comparison to result from food duplicate diet method. Int J Hyg Environ Health 2010; 213(6): 450-7.

Lee HS, Cho YH, Park SO, Kye SH, Kim BH, Hahm TS, el al. Dietary exposure of the Korean population to arsenic, cadmium, lead and mercury. J Food Comp Anal 2006; 19: S31-7.

Arnich N, Sirot V, Riviere G, Jean J, Noel L, Guerin T, et al. Dietary exposure to trace elements and health risk assessment in the 2nd French total diet study. Food Chem Toxicol 2012; 50(7): 2432-49.

Sand S, Becker W. Assessment of dietary cadmium exposure in Sweden and population health concern including scenario analysis. Food Chem Toxicol 2012; 50(3-4): 536-44.

Downloads

Published

29-09-2017

How to Cite

1.
Kluengklangdon P, Rojanapantip L, Jittiyossara K, Pornsapmanee N, Chinwattanawong P, Hemloha K. Risk Assessment of Dietary Exposure to Cadmium in the Thai Population. ว กรมวิทย พ [internet]. 2017 Sep. 29 [cited 2025 Dec. 28];59(3):181-98. available from: https://he02.tci-thaijo.org/index.php/dmsc/article/view/241152

Issue

Section

Original Articles