[2026-09-24] Ectopic Growth Hormone-Secreting Pituitary Neuroendocrine Tumor in the Sphenoid Region: A Case Report of an Unusual Location of Tumor That Causes Acromegaly

Jintanan Jangsiripornpakorn

doi:10.33165/rmj.2027.e281158

Authors

Jintanan Jangsiripornpakorn Diabetes and Metabolic Care Center, Division of Endocrinology, Department of Medicine, Taksin Hospital, Bangkok, Thailand https://orcid.org/0000-0002-2735-6862

DOI:

https://doi.org/10.33165/rmj.2027.e281158

Keywords:

Acromegaly, Pituitary neoplasms, Neuroendocrine tumors, Transsphenoidal surgery, Excessive growth hormone, Ectopic pituitary tumor

Abstract

Background: Acromegaly is almost always caused by a sellar growth hormone (GH)-secreting pituitary tumor, while ectopic pituitary neuroendocrine tumors (PitNETs) are exceedingly rare.

Case Presentation: This report a 44-year-old man with acromegaly and new-onset diabetes, whose sellar magnetic resonance imaging was normal but revealed a sphenoidal mass. Endoscopic transsphenoidal resection confirmed a GH-secreting PitNET. Postoperatively, he achieved biochemical remission and complete resolution of diabetes.

Conclusions: This case emphasizes the importance of considering ectopic PitNETs when acromegaly presents with normal pituitary imaging.

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