Phytochemical composition and pharmacological activities of herbal ingredients in Trikatuk remedy

Abstract

Trikatuk remedy has long been used in Thai traditional medicine for adaptogen or immunomodulatory agent for the treatment of diseases in the rainy season. Trikatuk remedy composed of 3 herbs including ginger (Zingiber officinale Roscoe.), pepper (Piper nigrum Linn.) and long pepper (Piper retrofractum Vahl.). This review is focused on the phytochemical composition and pharmacological activities of three components in Trikatuk remedies. The major constituents of ginger are gingerols and shogaols while. piperine The major compound in pepper and long pepper. The reviews of pharmacological activity of herbs in Trikatuk remedies found that ginger has the effect of relieving flatulence nausea, vomiting pain and inflammation. Pepper can increase blood flow to the uterus, analgesic activity, seizure control, anti-inflammatory and inhibitory effect on nitric oxide. Long pepper showed the lipid-lowering effects in the liver, anti-inflammatory, analgesic activity, gastroprotective effects and antibacterial effect, inhibiting lymphoma cancer cells, leukemia cells as well as the action against the dengue virus. Data from this review can be used as the basic information for the study of phytochemicals composition and pharmacological activity of Trikatuk remed.